目的利用氟桂利嗪(FNZ)研究钙离子拮抗剂对体外培养海马神经元缺血缺氧损伤的作用及其作用机制。
Objective To study the dual effects of calcium antagonists on ischemic hypoxic injury of hippocampal neurons cultured in vitro by using flunarizine (FNZ) and the mechanism of its action.
钙离子拮抗剂—尼莫地平有重要的脑保护作用。
Nimodipine, a calcium-channel antagonist has importment brain protection role.
方法：用荧光倒置显微镜来测定癫痫状态下海马CA1、CA3区钙超载的情况，并用钙离子拮抗剂尼莫地平作用于海马脑片看钙超载的变化。
Methods: calcium overloading in hippocampal CA1, CA3 region of epileptic rats was measured using a fluorescent inverted microscope, and the inhibition by the nimodipine was observed, too.
方法：用荧光倒置显微镜来测定癫痫状态下海马CA1、CA3区钙超载的情况，并用钙离子拮抗剂尼莫地平作用于海马脑片看钙超载的变化。
Methods: calcium overloading in hippocampal CA1, CA3 region of epileptic rats was measured using a fluorescent inverted microscope, and the inhibition by the nimodipine was observed, too.
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