DNA甲基化由DNA甲基转移酶催化，在多种调节因子的参与下，与组蛋白修饰相互作用，抑制基因转录，导致基因沉默。
DNA methylation catalyzed by DNA methyltransferases interacts with histone modification to inhibit gene transcription, induce gene silencing at the participation of many regulators.
认识药物代谢的酶学基础，了解药酶的常见底物、诱导剂和抑制剂，合理选用同类药品，能避免有害药物代谢性相互作用的发生。
The adverse drug interactions can be avoided by knowing the enzymology basis of drug metabolism, common substrates, inductors, inhibitors involved and using the same kind of drugs rationally.
结论CYP1A是介导肉桂酸代谢转化的主要酶系，肉桂酸与抑制或诱导CYP1A酶的药物合用可能存在相互作用。
CONCLUSION CYP1A is the major enzyme in metabolism of cinnamic acid. The medicine, which have inducible and inhibitory effects on CYP1A, may have interaction with cinnamic acid.
结论CYP1A是介导肉桂酸代谢转化的主要酶系，肉桂酸与抑制或诱导CYP1A酶的药物合用可能存在相互作用。
CONCLUSION CYP1A is the major enzyme in metabolism of cinnamic acid. The medicine, which have inducible and inhibitory effects on CYP1A, may have interaction with cinnamic acid.
应用推荐