本文主要概述了微生物来源的醛糖还原酶抑制剂的研究进展。
This review mainly gives a brief account of the progress of research on aldose reductase inhibitors from microorganisms.
因此，醛糖还原酶抑制剂成为公认的预防、改善和治疗糖尿病并发症的有效对策。
Therefore, ALR2 inhibition has received attention as an attractive strategy to prevent or delay the onset and to minimize the seriousness of chronic diabetic complications.
动物模型及体外实验结果显示，HMG - COA还原酶抑制剂能抑制肿瘤的生长。
Evidence from animal models and in vitro experiments suggests that HMG-coA reductase inhibitors are capable of suppressing tumor growth.
目的：从电子水平上探讨具有抗肿瘤活性的核苷酸还原酶抑制剂的定量构效关系（QSAR）。
Purpose: To study the QSAR of the ribonucleotide reductase inhibitors on the electron level.
观察了一种醛糖还原酶抑制剂（ICI 128436）对小鼠胰岛体外培养时山梨醇代谢的影响情况。
The effect of ICI 128436, an aldose reductase inhibitor on the sorbitol metabolism in the mouse pancreatic islets during in vitro culture was observed.
醛糖还原酶是多元醇代谢通路中的限速酶，醛糖还原酶抑制剂能有效抑制此通路，减慢或改善糖尿病并发症。
Aldose reductase is a key rate?limiting enzyme in the pathway, while aldose reductase inhibitors can inhibit the pathway and alleviate the symptoms of diabetic complications.
该方法已用于设计抑制剂大肠杆菌二氢叶酸还原酶和人类磷脂酶a2。
This method has been applied to the design of inhibitors for E. coli dihydrofolate reductase and human phospholipase A2.
美伐他汀是3羟甲基戊二酰辅酶a还原酶的有效的竞争性抑制剂，它是一种胆固醇生物合成调解酶。
Mevastatin is a potent competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-coa reductase, a regulatory enzyme for cholesterol biosynthesis.
美伐他汀是3羟甲基戊二酰辅酶a还原酶的有效的竞争性抑制剂，它是一种胆固醇生物合成调解酶。
Mevastatin is a potent competitive inhibitor of 3-hydroxy-3-methyl-glutaryl (HMG) -coa reductase, a regulatory enzyme for cholesterol biosynthesis.
美伐他汀是3羟甲基戊二酰辅酶a还原酶的有效的竞争性抑制剂，它是一种胆固醇生物合成调解酶。
Mevastatin is a potent competitive inhibitor of 3-hydroxy-3-methyl-glutaryl (HMG) -coa reductase, a regulatory enzyme for cholesterol biosynthesis.
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