结论左西替利嗪治疗慢性荨麻疹安全有效。
Conclusion Levocetirizine is an effective and safe agent for the treatment of CIU.
西替利嗪为第一代抗胺药物羟嗪的衍生物。
Cetirizine for the first generation of anti-drug hydroxyzine amine derivatives.
目的建立盐酸左西替利嗪片的含量测定方法。
The purpose of this article is to find a way to determine the effective content of Levo-cetirizine Hydrochloride tablets.
目的改进文献合成西替利嗪的方法，优化工业生产。
OBJECTIVE Improving traditional synthesis method of Cetirizine Hydrochloride to optimize industrial production technique.
本发明提供的盐酸西替利嗪是盐酸西替利嗪外用制剂。
The hydrochloric acid cetirizine is an external preparation of the hydrochloric acid cetirizine.
目的：评价左西替利嗪治疗常年性过敏性鼻炎的有效性和安全性。
AIM: To evaluate the efficacy and safety of levocetirizine and cetirizine in the treatment of perennial allergic rhinitis.
目的：评价左西替利嗪治疗常年性过敏性鼻炎的有效性和安全性。
Objective To investigate and compare the effect and safety of levocetirizine and cetirizine for the treatment of chronic idiopathetic urticaria (CIU).
目的：研究盐酸左西替利嗪治疗慢性特发性荨麻疹的疗效和安全性。
Objective:To evaluate the efficiency and safety of the new kind of second generation antihistamines(levoceti-rizine)in the treatment of chronic idiopathic urticaria.
目的：研究国产盐酸西替利嗪片的人体药代动力学和相对生物利用度。
Objective: To study the pharmacokinetics and relative bioavailability of domestic cetirizine hydrochloride tablet in healthy volunteers.
目的：制备盐酸西替利嗪缓释制剂以验证其缓释制剂延长药效的作用。
Objective:To Prepared cetirizine hydrochloride sustained-release preparations in order to confirm its extension of drug efficacy.
目的：研究国产盐酸西替利嗪胶囊的人体药代动力学和相对生物利用度。
Objective: To study the pharmacokinetics and relative bioavailability of domestic cetirizine hydrochloride capsule in healthy volunteers.
目的比较西替利嗪与酮替芬治疗学龄期儿童急性荨麻疹的疗效和不良反应。
Objective to compare the efficacys and adverse reaction between cetirizine and ketotifen fumarate in the treatment of acute urticaria for school children.
目的：建立毛细管电泳法测定盐酸西替利嗪糖浆剂中西替利嗪含量的方法。
Objective: To establish a capillary zone electrophoretic method for determining cetirizine in cetirizine HCL syrup.
目的：评价国产盐酸西替利嗪治疗荨麻疹和过敏性鼻炎的临床疗效和安全性。
Objective: To evaluate the efficacy and safety of domestic cetirizine HCL in the treatment of patients with urticaria and allergic rhinitis.
本发明是在西替利嗪中，配合作为稳定剂的碱性化合物形成口服制剂组合物。
The invention discloses an oral preparation composition prepared by being matched with an alkaline compound taken as a stabilizing agent in cetirizine.
结论盐酸左西替利嗪联合雷尼替丁治疗慢性荨麻疹较单用盐酸左西替利嗪效果好。
Conclusion Combined levocetirizine hydrochloride and ranitidine is better than only use of levocetirizine hydrochloride in the treatment of chronic urticaria.
结论西替利嗪可能通过抑制趋化因子mcp - 1的表达而发挥抗皮肤过敏作用。
CONCLUSION the role of cetirizine on the cutaneous allergy may be related to inhibiting the expression of MCP-1.
目的：建立盐酸西替利嗪胶囊含量及溶出度测定方法。方法：用高效液相色谱法测定。
Objective: to establish a HPLC method to determine the content of cetirizine hydrochloride and dissolution in its capsules.
结论：西替利嗪治疗常年变应性鼻炎与阿司咪唑比较具有起效快、不良反应少的特点。
CONCLUSION: the effect of cetirizine in treating perennial allergic rhinitis is faster and the adverse reaction is less than those of astemizole.
结果咪唑斯汀可抑制花生四烯酸诱导的小鼠耳部水肿，但氯雷他定和西替利嗪均不能；
Results Arachidonic acid-induced ear edema was reduced by mizolastine, but loratadine and cetirizine were not.
结论西替利嗪可能通过抑制角质形成细胞趋化因子的表达而发挥抗皮肤过敏炎症作用。
Conclusion Cetirizine may exert the anti-allergic inflammatory effects of skin by inhibiting the expression of chemokines in human keratinocytes.
以苯甲酰氯为原料，经酰化，还原，环合等反应合成左旋西替利嗪盐酸盐，反应总收率为8.05%。
Levocetirizine Dihydrochloride was prepared from benzoyl chloride by acidylation, hydrogenation, cyclization with an overall yield of 8.05%.
以苯甲酰氯为原料，经酰化，还原，环合等反应合成左旋西替利嗪盐酸盐，反应总收率为8。05%。
Levocetirizine dihydrochloride was prepared from benzoyl chloride by acids lation hydrogenation cyclization with an overall yield of8.05%.
论文通过三条路线，经化学拆分法或手性诱导合成法，对左旋西替利嗪及其中间体的合成进行了研究。
Three synthetic routes to prepare levocetirizine and its intermediates through chemical resolution and chiral induction were studied in the paper.
结果抗组胺药品种变化不大，但使用有集中现象，用药金额2004年有所下降，目前最常用的是酮替芬、西替利嗪、羟嗪和氯雷他定等。
Results Consumption of antihistamine agents decreased in 2004, and kinds of drugs selected had no obvious change, but it has concentrated phenomena.
结果抗组胺药品种变化不大，但使用有集中现象，用药金额2004年有所下降，目前最常用的是酮替芬、西替利嗪、羟嗪和氯雷他定等。
Results Consumption of antihistamine agents decreased in 2004, and kinds of drugs selected had no obvious change, but it has concentrated phenomena.
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