目的综述药物的生物药剂学性质对药物口服吸收的影响。
Objective To review the impacts of biopharmaceutical characteristics on oral drug absorption.
前药研究是提高生物药剂学分类系统中第III和IV类药物口服吸收的有效途径之一。
Prodrug is an effective way to improve the oral absorption of the drugs which belong to Biopharmaceuticals Classification System(BCS) class III and IV.
方法以国内外发表的文献为依据，总结归纳了壳聚糖及其衍生物促进药物口服吸收中的机理及影响因素。
METHODS Sum up the studies of the mechanism and influence factors of Chitosan and its Derivatives in oral drug absorption.
药物的溶解性，在胃肠道中的稳定性，膜的通透性和全身代谢是影响口服药物吸收的主要因素。
The solubility, stability in gastrointestinal tract, membrane permeability and presystemic metabolism of drugs were the major factors on oral drug absorption.
口服是最常用的给药途径，其吸收涉及药物通过胃肠道上皮细胞膜的转运。
For oral administration, the most common route, absorption refers to the transport of drugs across membranes of the epithelial cells in the GI tract.
氯化N-三甲基壳聚糖是壳聚糖的部分季铵化衍生物，能溶于中性及碱性环境中，可作为肽类药物的口服吸收促进剂。
Ntrimethyl chitosan chloride, a partially quaternised derivative of chitosan, which is soluble in neutral and basic environment, can be used as an absorption enhancer of oral peptide drugs.
结果药物的溶解性、稳定性、膜通透性和首过作用等生物药剂学性质是影响药物口服后经胃肠道吸收的主要因素。
Results The solubility, stability in gastrointestinal tract, membrane permeability and presystemic metabolism of drugs were the major factors on oral drug absorption.
如果没有发现口服吸收的药物，格林森医生将因此而受到牵连。
If no orally consumed drugs were found then Dr. Greenson would have been implicated.
利用非微粒脂质给药系统，药物不必经过溶出的步骤，从而可以显著的提高疏水性药物的口服吸收。
Oral absorption of hydrophobic drugs can be significantly improved using lipid-based non-particulate drug delivery systems, which avoid the dissolution step.
低生物利用度最常见于水溶性差、吸收慢的药物的口服剂型。
Low bioavailability is most common with oral dosage forms of poorly water-soluble, slowly absorbed drugs.
过度使用可能会通过减少肠道对营养物质和适当的过境速度增加口服药物的吸收。
Overuse may decrease absorption of nutrients and oral medications due to increased speed of transit through the intestines.
吸收过程是决定口服药物生物利用度的重要因素，然而很多药物的吸收机制还不明确。
The absorption process is an important factor in determining the bioavailability of orally administered drugs. however, the absorption mechanism of many drugs is not clear.
讨论了影响自胃肠道吸收药物生物利用度的因素，对提高难溶性药物口服生物利用度的方法进行了综述。
Factors that affect the oral bioavailability of water insoluble drugs were discussed, and a review was given on the measures of improving the oral bioavailability of water insoluble drugs.
固体剂型的吸收主要是出于方便、经济、药物稳定性、及病人接受性的考虑，大多数药物都以片剂或胶囊剂口服给药。
Absorption from solid forms: Most drugs are given orally as tablets or capsules primarily for convenience, economy, stability, and patient acceptance.
本实用新型解决了现有技术存在药物对浪费和长期口服药物对肠胃吸收有副作用的技术问题。
The utility model solves the technical problems of the waste of the medicine and the side effect caused by taking oral medicine for a long term in the prior art.
本实用新型解决了现有技术存在药物对浪费和长期口服药物对肠胃吸收有副作用的技术问题。
The utility model solves the technical problems of the waste of the medicine and the side effect caused by taking oral medicine for a long term in the prior art.
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