目的：创建缓释植入剂局部给药治疗系统的药动学模型。
Objective:To establish the pharmacokinetic model for a target therapeutic system of sustained-release implants.
本发明应用了药动学模型和药效学模型来确定最适的药物制剂和最适的施用参数。
A pharmacokinetic and pharmacodynamic model is employed to determine optimum drug formulations and optimum parameters for administration.
参数法包括十个药动学模型和三种药效学模型，可以同时求算药动学和药效学参数；
Parametric method which based on the theory of "effect compartment" suggested by Sheiner (1979) et al includes ten PK models and three PD models.
该模型综合了生理药动学模型和房室模型的优点，并提出了血药浓度衰减的频率因子。
It has the advantage of physiological pharmacokinetics model, its kinetic parameters have anatomic and physiological meanings, and its solution can be expressed succinctly like the atrium model.
药物浓度对时间数据作房室模型和统计矩解析，并求出相应的药动学参数。
Analysis of the data was executed by compartmental model and statistical moment calculation from which pharmacokinetic parameters were obtained.
结论天麻素注射液的人体药动学符合药动学二室模型。
Conclutions The pharmacokinetics of gastrodin injection in volunteers was accorded with two compartment model.
建立合理的药动学筛选模型不仅可以降低新药开发的成本，并且可以在新药研究早期对其作出正确的评价。
Establishing rational pharmacokinetic screening models can not only decrease the cost of finding new drugs, but also give a correct evaluation at the beginning of drug research.
目的：研究药动学房室模型的辨识问题。
OBJECTIVE: To study the identification problems of pharmacokinetic compartment models.
方法采用LC-MS/MS法测定血浆中甲氯噻嗪的浓度并用非房室模型计算药动学参数。
The concentration of methyclothiazide in blood plasma was measured by an validated LC-MS/MS method and were assessed with non-compartment model to obtain the pharmacokinetic parameters.
用非房室模型参数估算法计算药动学参数。
The pharmacokinetic parameters were calculated according to non - compartment model.
目的建立单室模型药物血管外多剂量给药的吸收和清除药动学的残数法计算方法。
Objective To establish a feathering method for processing the pharmacokinetic parameters of mono-compartment drugs administered by non-parenteral route by repeated doses.
目的建立单室模型药物血管外多剂量给药的吸收和清除药动学的残数法计算方法。
Objective To establish a feathering method for processing the pharmacokinetic parameters of mono-compartment drugs administered by non-parenteral route by repeated doses.
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