结论：化合物sipi -1 -3和4为首次报道的新结构化合物，抑制胆固醇生物合成活性也为新发现。
CONLUSION: Compound SIPI 1 3 and 4 were first reported with new structures, Their lowering cholesterol biosynthesis activities were first found so far.
综述了胆固醇生物合成过程及生物合成过程中关键酶抑制剂的研究开发现状。
Cholesterol biosynthetic pathway, status of research and development on inhibitors of key enzymes in cholesterol biosynthesis were reviewed.
酰基辅酶A：胆固醇酰基转移酶（ACAT）是细胞内唯一合成胆固醇酯的酶，在细胞和生物体胆固醇代谢平衡中起非常重要的作用。
Acyl-CoA: cholesterol acyltransferase(ACAT) is an intracellular enzyme that catalyzes the formation of cholesterol esters from long-chain fatty acyl coenzyme A and cholesterol.
首次合成出水溶性两亲性含胆固醇基的羧甲基纤维素钠衍生物(CCSD)。
The water soluble amphiphilic cholesteryl-bearing carboxymethylcellulose sodium derivative (CCSD) was first synthesized with the help of coupling agent and catalyst at room temperature.
从自然界含量丰富的胆固醇和简单芳香衍生物出发，经过简单的合成即可得到凝胶的前体。
Cholesterol abundant in the nature and simple aromatic derivative can be made into gel precursor just through simple synthesis.
在昆虫中，胆固醇不仅是细胞膜的重要成分之一，也是昆虫蜕皮激素生物合成的前体。
In insects, cholesterol is not only one of the main components of cell membranes, but also a precursor of ecdysone biosynthesis.
美伐他汀是3羟甲基戊二酰辅酶a还原酶的有效的竞争性抑制剂，它是一种胆固醇生物合成调解酶。
Mevastatin is a potent competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-coa reductase, a regulatory enzyme for cholesterol biosynthesis.
美伐他汀是3羟甲基戊二酰辅酶a还原酶的有效的竞争性抑制剂，它是一种胆固醇生物合成调解酶。
Mevastatin is a potent competitive inhibitor of 3-hydroxy-3-methyl-glutaryl (HMG) -coa reductase, a regulatory enzyme for cholesterol biosynthesis.
美伐他汀是3羟甲基戊二酰辅酶a还原酶的有效的竞争性抑制剂，它是一种胆固醇生物合成调解酶。
Mevastatin is a potent competitive inhibitor of 3-hydroxy-3-methyl-glutaryl (HMG) -coa reductase, a regulatory enzyme for cholesterol biosynthesis.
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