这一新的解释把以往关于BCA1作用机制各不相干的理论整合到一起,对其他肿瘤抑制因子作用机制的了解可能带来帮助。
This explanation brings together many disparate theories about how the gene functions and could also shed light on how other tumour suppressors work.
PTEN肿瘤抑制因子在乳腺癌中虽常呈失表达,但并不是通过基因突变或促进子甲基化而实现的,因此其失表达的机制还不清楚。
Expression of the PTEN tumor suppressor is frequently lost in breast cancer in the absence of mutation or promoter methylation through as yet undetermined mechanisms.
类似的相反作用在其他肿瘤抑制因子中也有发现,但H - REV107 - 1的表达与非小细胞肺癌病人存活期的关联还是相当令人震惊。
Similar reverse functions have been identified for other tumor suppressors, but the correlation between H-REV107-1 expression and NSCLC patient survival is quite striking.
她说这也就可以解释为什么试图通过血管生成抑制因子来阻断血管生长信号而阻断肿瘤血液供应的药物通常在六周内失去作用。
She says that this could explain why cancer drugs aimed at choking off a tumor's blood supply by blocking growth signals, known as angiogenesis inhibitors, usually stop working within about 6 months.
结论:HIFU治疗可以减少肿瘤局部免疫抑制因子的表达,推测其有利于肿瘤宿主免疫平衡的恢复。
Conclusions: HIFU treatment could reduce the expression of local immunosuppressive factors. It would be helpful to the recovery of the balance between host antitumor immunity and tumor escape.
TGF配体虽然在早期肿瘤中作为肿瘤抑制基因发挥作用,但其在进展期肿瘤中却变成有效的促转移因子。
TGF ligands act as tumor suppressors in early stage tumors but are paradoxically diverted into potent prometastatic factors in advanced cancers.
贝伐单抗通过抑制被称为血管内皮生长因子的蛋白,来抑制肿瘤组织的新生血管的生长。
Bevacizumab blocks a protein called vascular endothelial growth factor, thus inhibiting the production of new blood vessels around tumors.
结论实验表明,水蛭素活性因子对S180肿瘤和CAM新生血管具有较强的抑制作用。
ConclusionThe experiments show that hirudin active factors have strong inhibition effect on S180 Tumor and CAM angiogenesis.
本研究表明,干扰素可以通过抑制肿瘤依赖性转录因子的表达来达到抑制肿瘤的作用,这种转录因子可以调控肿瘤细胞的生长。
The present study indicates that interferon can suppress cancer growth by inhibiting expression of a cancer-dependent transcription factor that controls genes that regulate cancer cell growth.
凋亡抑制因子在肿瘤进展中的作用日益受到人们的关注。
We are attracted by the function of inhibitor of apoptosis in carcinoma progression.
目的观察妇科恶性肿瘤患者血清、腹腔液中巨噬细胞移动抑制因子(MIF)的表达及其与恶性肿瘤的相关性。
Objective to investigate the expressions of macrophage migration inhibitory factor (MIF) in gynecologic malignancy tumor patients and the correlation between VEGF and CA125.
目的探讨直肠癌组织中脑特异性血管生长抑制因子1 (BAI1)基因的表达情况及BAI1对肿瘤血管生成和肿瘤生长的作用。
Objective to explore the expression of brain-specific angiogenesis inhibitor 1 (BAI1) gene in rectal cancer tissues and its effect on growth and angiogenesis of the tumor.
摘要肿瘤的化学预防,即应用天然的、合成的或者生物化学因子逆转、抑制或阻止肿瘤进展为浸润性肿瘤。
Cancer chemoprevention is defined as the use of natural, synthetic, or biologic chemical agents to reverse, suppress, or prevent carcinogenic progression to invasive cancer.
血管形成是实体肿瘤增殖和转移的关键步骤,这一过程依赖于内源性刺激因子和抑制因子之间的平衡。
Angiogenesis is the key step in tumors proliferation and metastasis, which depends on the net balance between endogenous stimulators and inhibitors.
本文综述了包括肿瘤坏死因子抑制剂、白细胞介素1抑制剂、干细胞移植及基因治疗等生物治疗在类风湿性关节炎治疗中的作用。
This article reviews the effect of biotherapy in ra including tumor necrosis factor inhibitor, IL-1inhibitor, stem cell transplantation genetic therapy and so on.
肿瘤坏死因子受体抑制剂,人可溶性,重组。
Tumor Necrosis Factor Receptor Inhibitor, Human Soluble, recombinant.
目的:研究T细胞在巨噬细胞游走抑制因子(MIF)基因修饰的瘤苗诱导抗肿瘤免疫反应中的作用。
Objective: To investigate the role of t cell in the antitumor immune responses induced by MIF gene modified tumor vaccine.
当促进因子的作用强于抑制因子时,便会引起肿瘤血管的生长。
When the effects of enhancing factors are stronger than those of inhibiting factors, it will cause unrestricted tumor neovascularization.
肿瘤血管生成是肿瘤生长转移的关键步骤,是促血管生成因子和抑制因子作用失衡的结果。
Tumor angiogenesis, resulting from the imbalance of angiogenic cytokines and angiogenesis inhibitors, is crucial for tumor growth and metastasis.
转录因子NF-IL6特异地在肿瘤组织中过量表达,许多报道表明抑制它的功能对肿瘤治疗有利。
NF-IL6 is specifically overexpressed in tumor tissues. Many reports have shown that abrogation of transcriptional activation activity is useful for tumor therapy.
目的观察血管内皮生长因子(VEGF)抗体对大鼠c6胶质瘤细胞凋亡的影响及对肿瘤生长的抑制作用。
Objective to observe the affect of vascular endothelial growth factor (VEGF) antibody on the cell apoptosis and growth of rat C6 glioma.
内皮抑素是一种抗血管生成的抑制因子,它特异性地作用于新生微血管的内皮细胞,其水平与肿瘤血管生成有着明显的相关性。
Endostatin is a kind of angiogenesis inhibitor, specific effecting in the new microvascular endothelial cells. The level of endostatin and the angiogenesis of tumor have a close correlation.
目的:探讨间接酶联免疫吸附试验(ELISA)检测核糖核酸酶抑制因子(RI)在恶性肿瘤患者血清中的表达。
Objective: To detect the expression of ribonuclease inhibitor (RI) in the serum of patients with malignant tumors by indirect ELISA.
血管生成促进因子和血管生成抑制因子的平衡控制着肿瘤新生血管的形成。
Formation of tumor new vessels is controlled by balances between angiogenic stimulators and inhibitors.
目的克隆和表达一种新的血管形成抑制因子,并研究其抗肿瘤活性。
Objective A new angiogenesis inhibitor HIAF 1 (human inhibitor angiogenesis factor 1) was cloned, expressed in E.
内皮抑素是一种新的能强烈抑制血管形成的抑制因子,内皮抑素水平与肿瘤具有明显的相关性,其水平可以作为肿瘤的临床预后指标。
Endostatin is a new inhibitor factor which can intensively inhibit angiogenesis. The level of endostatin is significantly related to tumor, which can be a prognostic indicator of tumor.
肿瘤抑制蛋白p21Waf1/Cip1可以作为细胞周期的抑制因子。
The tumor suppressor protein p21 Waf1/Cip1 acts as an inhibitor of cell cycle progression.
肿瘤坏死因子抑制剂已经证明成功,减少AS疾病活动在数量有限的临床试验。
Tumor necrosis factor inhibitors have demonstrated success in reducing as disease activity in a limited number of clinical trials.
肿瘤坏死因子抑制剂已经证明成功,减少AS疾病活动在数量有限的临床试验。
Tumor necrosis factor inhibitors have demonstrated success in reducing as disease activity in a limited number of clinical trials.
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