目的研究缓激肽（BK）对脑胶质瘤大鼠血肿瘤屏障紧密连接的影响。
Objective To investigate the effect of bradykinin (BK) on tight junction (TJ) of the blood-tumor barrier (BTB) and interendothelial TJ of capillaries in brain glioma rats.
2009年，发表在《癌症研究》上的一篇论文指出，新型的纳米粒子可以穿过屏障，并附着在肿瘤组织上。
A 2009 study published in the journal Cancer Research showed that specially-engineered nanoparticles can cross the barrier and attach to tumor tissue.
一旦转移的肿瘤细胞穿过血脑屏障，脑微环境会对肿瘤定植和生长同时发挥抑制和促进作用。
Once disseminate tumor cells pass through the blood-brain barrier, the brain microenvironment could elicit both inhibiting and promoting effects on tumor colonization and outgrowth.
结果模拟结果很好地反映了肿瘤内异常的血液动力学特性，以及由此造成的药物输运屏障、浓度分布不均匀性等特征。
ResultsThe model successfully reflected abnormal tumor hemodynamics, which results in impeded drug delivery and uneven concentration distribution of the drug.
由于大部分化疗药物难以通过血脑屏障，脑部肿瘤的化疗效果不佳。
Since most of the chemotherapy drugs cannot pass the blood-brain barrier, the effect of chemotherapy for brain tumor is disappointing.
瘤内放射治疗是将放射性药物直接置于肿瘤残腔内，直接作用于胶质瘤细胞，此法能避开血脑屏障同时也能提高局部药物浓度。
Radiation therapy for tumors is that radioactive substances is directly placed in the tumor residual cavity, to avoid the blood-brain barrier and improve local drug concentration.
瘤内放射治疗是将放射性药物直接置于肿瘤残腔内，直接作用于胶质瘤细胞，此法能避开血脑屏障同时也能提高局部药物浓度。
Radiation therapy for tumors is that radioactive substances is directly placed in the tumor residual cavity, to avoid the blood-brain barrier and improve local drug concentration.
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