方法:以辛二酸为起始原料,经缩合、活化、氨解合成SAHA。
Methods: Suberic acid was selected as the start material, and the SAHA was obtained through condensation, activation and ammoniated.
合成脂肪族聚酯二醇的合成及二羧酸经缩合聚合,和已知的完全生物降解土壤和水。
Synthetic aliphatic polyesters are synthesised from diols and dicarboxylic acids via condensation polymerisation, and are known to be completely biodegradable in soil and water.
以2 -溴丁烷和尿素作为起始原料,经缩合、环化、溴代三步反应得到除草定,总收率为61%。
Bromacil was synthesized using 2-bromobutane and urea as the starting materials in three steps including condensation, cyclization and bromination with total yield of 61%.
方法以对硝基苯甲酰氯为起始原料,经缩合、还原、重氮化、偶合、成盐等反应制得巴柳氮二钠。
METHODS Balsalazide disodium was synthesized by reactions of condensation , reduction, diazotization , coupling and salification from 4-nitrobenzoyl chloride.
目的探讨改进合成普拉洛芬的方法方法以2-氯烟酸原料经缩合、还原、取代、酰化等制得普拉洛芬。
Objective To study the synthetic method of pranoprofen. Methods Pranoprofen was synthesized from 2-chloronicotinic acid by condensation, reduction, substitution and acylation.
以对甲苯乙酮和三氟醋酸乙酯为原料,经缩合、环合两步反应得到2型环氧酶抑制剂赛来昔布,总收率为6 7%。
Celecoxib as a cyclooxygenase-2 inhibitor, was synthesized from p-methylacetophenone and ethyl trifluoroacetate by successively condensation and cyclization in 67% overall yield.
方法以肉桂醇为原料,经酯化、氨化和缩合-环合而得。
METHODS Cilnidipine was synthesized from cinnamyl alcohol by esterification, feminization and condensation - cyclization.
以乙醇胺为起始原料,经亲核取代、肖特一鲍曼反应和缩合反应制得吗氯贝胺,总收率可达71.2%。
Moclobelide was synthesized from ethanolamine by nucleophilic substitution and Schotten-Baumann reaction, followed by condensation with an overall yield of 71.2%.
以茶碱为原料经取代、氧化和缩合反应制备多索茶碱;其结构为IR及MS所证实。
Doxofylline was synthesized from theophylline by substitution, oxidation and condensation. The structure has been proven by IR and MS.
方法:以芦丁为原料,经苯甲酰化,水解,糖苷缩合和脱保护合成目标化合物。
Methods: Rutin was utilized as the starting material. The target compounds were produced via benzoylation, hydrolysis, glycosidation and deproteination.
IR光谱分析同样反映出沥青经催化氧化后分子结构中侧链减少,芳环上的氢减少,整个芳环的缩合程度增加。
Meanwhile IR analysis showed that side chain between molecule and hydrogen of aromatic ring were decreased, condensed degree was increased in catalytic oxidation.
在碱性催化剂的存在下,甲醛和丁醛经羟醛缩合反应合成2,2—二羟甲基丁醛。
Respectively using barium hydroxide and a basic anion exchanger as a catalyst, 2, 2-bis (hydroxymethyl) butyraldehyde is prepared from the Aldol condensation of butyraldehyde with formaldehyde.
本文用花生油经甲酯化后,直接与二乙醇胺缩合制备烷醇酰胺,并讨论了反应条件如原料配比、反应温度和时间对产品性能的影响。
To synthesis of Alkanolamide from the peanut-oil Acid methyl Ester. Some influences of starting burden, reaction temperature and time were discussed.
对溴苯酚经烷基化、硫酸二甲酯醚化、缩合及水解反应制得阿达帕林,总收率51%。
Adapalene was synthesized from 4-bromophenol by alkylation, etherification, condensation and hydrolysis with an overall yield of 51%.
方法:以廉价易得的谷氨酸和丙氨酸为起始原料,经端基保护、脱保护、缩合等步骤得到一个有效的合成路线。
Methods: An efficient route was started from the cheaper materials alanine and glutamic acid via protection, deprotection and coupling reactions.
采用原料芴经硝化、还原反应得到2-氨基芴,再与一系列的芳香醛缩合得到相应的席夫碱类化合物。
The condensations of 2-aminofluorene with a series of aldehyde gave the corresponding schiff bases(a~h), and their structures were confirmed by IR, 1H NMR, MS and elemental analysis.
方法:以庚二酸单乙酯为原料,经酰氯化、傅克酰化、还原、水解、缩合及氧化反应合成塞曲司特。结果:塞曲司特的总产率为5 0 .7%。
Methods and results:Through acylation, Friedel Crafts reaction, reduction, hydrolysis, condensation and oxidation, the title compound was prepared with a total yield of 50.7%.
用己二胺、 己二酸及双功能团的氯化螺环磷酸酯经界面缩合制得含磷尼龙66。
Phosphorus containing ny1on-66 was prepared by the interphase condensation between adipic acid, hexamethylenediamine and dichloropentate.
以3-吲哚甲酸为起始原料,经氯化亚砜酰氯化、与托品醇缩合合成了托烷司琼盐酸盐。
Tropisetron Hydrochloride was synthesized from 1Hindol-3-carboxylic acid by chloride acetylation and condensation with Tropic alcohol.
方法原甲酸三乙酯与氰乙酸乙酯缩合,然后和羟乙基肼经环合、水解等一锅法合成5-氨基吡唑-4-甲酸,然后在亚硫酸钠存在条件下加热脱羧得到5-氨基-1-羟乙基吡唑。
METHODS 5-amino-1-hydroxyethyl pyrazole-4-carboylic acid was synthesized through condensation of ethyl cyanoacetate and triethyl orthoformate followed by one-pot methodology of cyclization, hydolysis.
方法原甲酸三乙酯与氰乙酸乙酯缩合,然后和羟乙基肼经环合、水解等一锅法合成5-氨基吡唑-4-甲酸,然后在亚硫酸钠存在条件下加热脱羧得到5-氨基-1-羟乙基吡唑。
METHODS 5-amino-1-hydroxyethyl pyrazole-4-carboylic acid was synthesized through condensation of ethyl cyanoacetate and triethyl orthoformate followed by one-pot methodology of cyclization, hydolysis.
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