• 方法以辛二起始原料缩合活化氨解合成SAHA

    Methods: Suberic acid was selected as the start material, and the SAHA was obtained through condensation, activation and ammoniated.

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  • 合成脂肪族聚酯的合成羧酸缩合聚合已知完全生物降解土壤

    Synthetic aliphatic polyesters are synthesised from diols and dicarboxylic acids via condensation polymerisation, and are known to be completely biodegradable in soil and water.

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  • 以2 -丁烷尿素作为起始原料缩合、环化、三步反应得到除草定,收率为61%。

    Bromacil was synthesized using 2-bromobutane and urea as the starting materials in three steps including condensation, cyclization and bromination with total yield of 61%.

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  • 方法对硝基苯甲酰为起始原料,缩合还原、重氮化、偶合、成盐等反应制得巴氮二

    METHODS Balsalazide disodium was synthesized by reactions of condensation , reduction, diazotization , coupling and salification from 4-nitrobenzoyl chloride.

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  • 目的探讨改进合成普拉洛方法方法2-氯烟酸原料缩合还原取代酰化等制得普拉洛芬。

    Objective To study the synthetic method of pranoprofen. Methods Pranoprofen was synthesized from 2-chloronicotinic acid by condensation, reduction, substitution and acylation.

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  • 以对甲苯三氟醋酸乙酯为原料,缩合环合两步反应得到2型环氧抑制剂赛来布,收率为6 7%。

    Celecoxib as a cyclooxygenase-2 inhibitor, was synthesized from p-methylacetophenone and ethyl trifluoroacetate by successively condensation and cyclization in 67% overall yield.

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  • 方法肉桂为原料,酯化、氨化缩合-环合而得

    METHODS Cilnidipine was synthesized from cinnamyl alcohol by esterification, feminization and condensation - cyclization.

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  • 乙醇胺为起始原料,亲核取代、肖特鲍曼反应缩合反应制得吗氯贝胺,收率可达71.2%。

    Moclobelide was synthesized from ethanolamine by nucleophilic substitution and Schotten-Baumann reaction, followed by condensation with an overall yield of 71.2%.

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  • 茶碱为原料取代氧化缩合反应制备多索茶碱结构IRMS所证实

    Doxofylline was synthesized from theophylline by substitution, oxidation and condensation. The structure has been proven by IR and MS.

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  • 方法:以芦丁原料苯甲酰化,水解糖苷缩合脱保护合成目标化合物

    Methods: Rutin was utilized as the starting material. The target compounds were produced via benzoylation, hydrolysis, glycosidation and deproteination.

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  • IR光谱分析同样反映沥青催化氧化后分子结构减少环上减少,整个芳环的缩合程度增加

    Meanwhile IR analysis showed that side chain between molecule and hydrogen of aromatic ring were decreased, condensed degree was increased in catalytic oxidation.

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  • 碱性催化剂的存在下,甲醛缩合反应合成2,2—二羟甲基丁醛。

    Respectively using barium hydroxide and a basic anion exchanger as a catalyst, 2, 2-bis (hydroxymethyl) butyraldehyde is prepared from the Aldol condensation of butyraldehyde with formaldehyde.

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  • 本文用花生油甲酯化后,直接与二乙醇胺缩合制备烷醇酰胺,并讨论了反应条件如原料配比、反应温度时间产品性能影响。

    To synthesis of Alkanolamide from the peanut-oil Acid methyl Ester. Some influences of starting burden, reaction temperature and time were discussed.

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  • 对溴苯酚烷基化硫酸二甲酯醚化缩合水解反应制得阿达帕林,收率51%。

    Adapalene was synthesized from 4-bromophenol by alkylation, etherification, condensation and hydrolysis with an overall yield of 51%.

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  • 方法:以廉价易得的谷氨酸氨酸为起始原料,端基保护保护、缩合等步骤得到一个有效合成路线

    Methods: An efficient route was started from the cheaper materials alanine and glutamic acid via protection, deprotection and coupling reactions.

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  • 采用原料芴硝化、还原反应得到2-氨基,再一系列的芳香醛缩合得到相应席夫碱类化合物

    The condensations of 2-aminofluorene with a series of aldehyde gave the corresponding schiff bases(a~h), and their structures were confirmed by IR, 1H NMR, MS and elemental analysis.

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  • 方法:以庚二酸单乙酯原料,氯化、傅克酰化、还原、水解、缩合氧化反应合成塞曲司特。结果:塞曲司特总产率为5 0 .7%。

    Methods and results:Through acylation, Friedel Crafts reaction, reduction, hydrolysis, condensation and oxidation, the title compound was prepared with a total yield of 50.7%.

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  • 二胺、 己二及双功能团的氯化螺环磷酸酯界面缩合制得含尼龙66。

    Phosphorus containing ny1on-66 was prepared by the interphase condensation between adipic acid, hexamethylenediamine and dichloropentate.

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  • 以3-吲哚甲酸为起始原料,氯化亚砜酰氯化、托品缩合合成了托烷司琼盐酸盐。

    Tropisetron Hydrochloride was synthesized from 1Hindol-3-carboxylic acid by chloride acetylation and condensation with Tropic alcohol.

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  • 方法甲酸三乙氰乙酸乙酯缩合,然后羟乙基肼环合、水解等一法合成5-氨基吡唑-4-甲酸,然后在亚硫酸钠存在条件下加热脱羧得到5-氨基-1-乙基吡唑。

    METHODS 5-amino-1-hydroxyethyl pyrazole-4-carboylic acid was synthesized through condensation of ethyl cyanoacetate and triethyl orthoformate followed by one-pot methodology of cyclization, hydolysis.

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  • 方法甲酸三乙氰乙酸乙酯缩合,然后羟乙基肼环合、水解等一法合成5-氨基吡唑-4-甲酸,然后在亚硫酸钠存在条件下加热脱羧得到5-氨基-1-乙基吡唑。

    METHODS 5-amino-1-hydroxyethyl pyrazole-4-carboylic acid was synthesized through condensation of ethyl cyanoacetate and triethyl orthoformate followed by one-pot methodology of cyclization, hydolysis.

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