治疗胰腺肿瘤一项重要的挑战是如何来克服这些肿瘤使免疫细胞耐受甚至支持肿瘤生长的能力。
A major challenge in treating pancreatic tumors is overcoming their ability to force immune cells to tolerate and even support their growth.
但动物模型研究显示B细胞在促进免疫耐受中可能也起作用。
Work in animal models indicates that B cells also may help promote immune tolerance.
关于免疫耐受的近期研究集中在一种称为调节性T细胞(Treg)的T细胞亚群的作用。
Recent studies of immune tolerance have focused on the role of a subset of t cells, called regulatory t cells (Tregs).
吗啡通过作用于神经突触来缓解疼痛，但它同时也兴奋了胶质细胞，可能也加剧了该药的副作用，如嗜睡，耐受，疼痛加剧和成瘾。
Morphine deadens pain by acting at nerve synapses, but it also activates glial cells, possibly worsening the drug's side effects, such as drowsiness, tolerance, worsening of pain, and addiction.
能否请您谈谈抗B细胞疗法诱导移植耐受治疗策略的可能性？
Can you talk about the possibilities of strategies for B cell-directed therapy for the induction of transplant tolerance?
然而，有些T细胞处于未激发状态，事实上他们被称为无反应性，耐受性的过程灭活了。
However, some t cells are not activated, in fact they are inactivated by a process called anergy or tolerance.
在产生免疫耐受的移植物中可发现调节性T淋巴细胞，并对移植组织具有保护性作用。
Regulatory T cells can be found in tolerated grafts and contribute to the acquisition of a state of privilege in those tissues.
目的：研究耐受状态下NK细胞功能抑制的机制。
Objective: To investigate the inhibition mechanism of T cells under tolerant condition to NK cell functions.
与此相反，更小耐受性、更大毒性的靶因子必须在更长时间里被严格管理，这些肾细胞癌疫苗必须仅仅在有限时期内给药。
In contrast with less tolerated more toxic targeted agents that must be administered for extended periods of time, these RCC vaccines must only be given for a limited period.
克隆不应答和抑制细胞是耐受的主要机制。
Clonal anergy and suppressor cells are main mechanisms of the tolerance.
目的利用大鼠异位心脏移植模型，探讨门静脉注射供体脾细胞诱导免疫耐受的机制。
Objective on the rat model of heterotopic heart transplantation, the mechanism of immune tolerance induced by portal venous injection of donor spleen cells was studied.
调节性T细胞介导的免疫调节是自身耐受的重要机制之一。
Immunoregulation mediated by regulatory t cell is one of the most important mechanisms to maintain self tolerance.
近年来，越来越多的研究表明CD4+CD25+调节性T细胞在免疫耐受的过程中起着非常重要的作用。
More and more research proved that CD4+CD25+ regulatory T cells (Treg cells) play an important role in immune tolerance in these years.
结论有些长期携带功能良好移植肾的患者已经获得对供者细胞特异的免疫耐受状态。
Conclusion Some of the patients carrying long - term and well - functioning renal grafts had become immunologic tolerant to donor cells.
而HBV感染导致T细胞免疫耐受的确切机制还不清楚。
The mechanisms responsible for the T cell tolerance in chronic HBV infection are not completely understood.
胸腺执行着重要的T细胞中枢耐受。
并在此基础上，研究木材中细胞次生代谢产物——二苯乙烯类化合物的含量与木材对真菌腐朽耐受性的相关性。
On the basis of this, the relationship between concentrations of stilbenes in the samples and the heartwood resistant ability was studied.
目的：观察异基因脾细胞经门静脉途径输注诱导受体免疫耐受的效果，以及联合使用塞尼哌后的效果。
Objective: to study the effects of immunological tolerance induced by administration of allogeneic splenocytes through portal vein in rats in combination with Daclizumab.
一些糖类，特别是海藻糖，能提高一些低等生物或细胞对干燥环境的耐受性，但如何将糖类导入细胞内又是一个挑战。
Some sugars, especially trehalose, can be more tolerant of some organism or cells to dry environments, But, how to bring sugars into cells is a challenge.
结论：吗啡影响神经细胞嘌呤核苷酸代谢，使细胞内腺苷酸及腺苷水平增高，这可能是吗啡依赖和耐受形成的机理之一。
Conclusion morphine may affect purine nucleotide metabolism of nerve cells, increase the adenylate and adenosine levels, which may be one of the mechanism of morphine dependence and tolerance.
HSP70在细胞应激保护、热耐受、凋亡、炎症与免疫反应中均发挥其重要的生物学效应。
HSP70 plays a critical biological role in cells' stress protection, heat endurance, apoptosis, inflammation, and immunity reaction.
中药可能通过自分泌或旁分泌增加滋养细胞HB - EGF表达，增强滋养细胞的增殖及侵入和对缺氧的耐受。
Chinese Herbs may enhance expression of HB-EGF on trophoblast through autocrine and paracrine role, and may enhance proliferation, invasion and tolerance anoxia of trophoblast.
近年来，调节性T细胞在自身耐受和抑制同种异体排斥反应中的作用受到越来越多的重视。
Recently, accumulating evidences have shown that regulatory t cells play a key role both in maintenance of self tolerance and tolerance to allograft.
结论骨髓间充质干细胞上清可抑制单核细胞来源的树突状细胞的成熟和功能，诱导免疫耐受。
Conclusion Human bone marrow mesenchymal stem cells inhibit maturation and function of monocyte-derived dendritic cells and induce immune tolerance.
结论嵌合状态与肾移植耐受存在明显相关性，克隆不应答、抑制细胞参与了耐受的形成。
Several other mechanisms may by theorized for the induction of tolerance in this renal transplant model, including clonal anergy and suppressive cells.
越来越多的研究表明调节T细胞是外周免疫耐受的关键。
More recent researches have shown that regulatory t cell is a key element in peripheral tolerance.
分析HBV感染时抗原特异性T细胞免疫耐受机制，并通过打破免疫耐受预防HBV感染。
This paper analyzed the mechanism of antigen-specific T cell tolerance during HBV infection in order to prevent HBV infection via breaking immune tolerance.
分析HBV感染时抗原特异性T细胞免疫耐受机制，并通过打破免疫耐受预防HBV感染。
This paper analyzed the mechanism of antigen-specific T cell tolerance during HBV infection in order to prevent HBV infection via breaking immune tolerance.
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