PHB1是一个30kda的肿瘤抑制蛋白，参与细胞周期控制(1)。
PHB1 is 30kda tumor suppressor protein involved in cell cycle control (1).
原癌基因的突变导致的过度刺激细胞周期，而突变的肿瘤抑制基因，会导致在这一功能的控制过度活动。
Oncogenes are mutations that cause an excessive stimulation of the cell cycle, while mutations in tumor suppressor genes can result in a loss in function in controlling this excessive activity.
E2F转录因子是控制细胞周期的关键调控因子。
The E2F transcription factors are key regulators in cell cycle regulation.
AT M激酶调节许多蛋白，涉及细胞周期检验点的控制、细胞凋亡和DNA修复。
ATM kinase regulates a number of proteins involved in cell cycle checkpoint control, apoptosis, and DNA repair.
结论翼状胬肉中细胞周期蛋白依赖性激酶抑制剂p16的低表达可能导致翼状胬肉细胞周期紊乱，其增殖失去控制。
Conclusion The lower expression of cell circle related kinase inhibitor in pterygium may play an important role on proliferation and pathogenesis of pterygium.
结论翼状胬肉中细胞周期蛋白依赖性激酶抑制剂p16的低表达可能导致翼状胬肉细胞周期紊乱，其增殖失去控制。
Conclusion The lower expression of cell circle related kinase inhibitor in pterygium may play an important role on proliferation and pathogenesis of pterygium.
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