这两种酶是组蛋白乙酰转移酶(它能给蛋白质添加乙酰基)和甲基化dna结合蛋白- 2(它能把DNA上的甲基去除)。
The enzymes in question are histone acetyltransferase (which adds acetyl groups to proteins) and methylated DNA-binding protein-2 (which removes methyl groups from DNA).
我们的数据提供了一个在基因组功能中组蛋白甲基化和染色质组织的新观点。
Our data provide new insights into the function of histone methylation and chromatin organization in genome function.
一组称为多梳抑制复合物1（PRC1）蛋白质沉默基因必须先结合到特定的组蛋白上的甲基化位点。
A group of proteins called the polycomb repressive complex 1 (PRC1) that silences genes must first bind to a particular methylated address on a histone and.
当甲基加到组蛋白后，这些基团会修饰它的性质并改变它上面特定基因的表达频率。
When methyl groups are added to a histone, they modify its properties and alter the frequency at which a particular gene is expressed.
DNA的低甲基化可能在异常组蛋白修饰的协同下引起某些T细胞基因的异常活化，导致狼疮自身免疫的发生。
DNA hypomethylation, likely to be cooperating with aberrant histone modification, may induce the activation of some t cell genes and development of autoimmunity in SLE.
过去甲基化的结构研究被阻碍的原因是因为很难制备组蛋白特定部位赖氨酸甲基化的均一样品。
Past structural studies of methylation were hindered by the extreme difficulty of constructing homogeneous samples of histones bearing methyl groups attached to specific lysine residues.
组蛋白H3第27位赖氨酸的甲基化与同源盒基因沉默、X染色体失活、基因印记等基因沉默现象有关；
The methylation of histone H3-K27 was proved to be linked to several silencing phenomena including homeotic-gene silencing, X inactivation and genomic imprinting.
核心过程的表观遗传的产业包括DNA甲基化、组蛋白改性、核小体重建、核染色质动力学和互动子都存在。
Core processes of epigenetic inheritance include DNA methylation, histone modification, nucleosome remodeling, nuclear dynamics and chromatin interaction with non-coding RNAs.
组蛋白赖氨酸甲基化在基因表达调控中的作用已成为表观遗传学研究的热点。
The role of histone lysine methylation in the gene expression regulation has turned into the hotspot of epigenetics.
总结了组蛋白精氨酸甲基化修饰体系的最新研究进展。
Here, the most recent progresses in the methylation studies of histone arginine were summa.
我们将在分析组蛋白修饰和DNA甲基化数据的背景下，讨论解决这些挑战的方法。
We will discuss methods to address these challenges in the context of analyzing histone modifications and DNA methylation data.
主要探讨组蛋白共价修饰中乙酰化和甲基化在消化道肿瘤形成过程中的作用。
This review focuses on how aberrant covalent histone modifications such as acetylation and methylation may contribute to the development of alimentary canal neoplasms.
目的观察dna甲基化和组蛋白乙酰化对人结肠癌细胞系癌相关基因的表达和细胞周期的影响。
Purpose to investigate the effects of DNA methylation and histone acetylation on the expression of tumor associated genes and cell cycle progression in human colonic cancer cells.
组蛋白赖氨酸的甲基化在真核基因表观遗传调控中起着关键作用。
Histone lysine methylation plays a key role in epigenetic regulation of eukaryotic genes.
DNA甲基化由DNA甲基转移酶催化，在多种调节因子的参与下，与组蛋白修饰相互作用，抑制基因转录，导致基因沉默。
DNA methylation catalyzed by DNA methyltransferases interacts with histone modification to inhibit gene transcription, induce gene silencing at the participation of many regulators.
组蛋白赖氨酸甲基化是组蛋白尾段发生的一种重要共价修饰，在基因的表观遗传转录调控中起着关键的作用。
The methylation of histone lysine is an important covalent modification at its tails and plays a key role in epigenetic regulation.
组蛋白赖氨酸去甲基化酶有可能成为一个新的抗肿瘤治疗靶标。
Therefore, histone lysine demethylases may serve as a new target for anti-cancer therapy.
表观遗传学涉及的机制主要包括DNA甲基化和组蛋白修饰及染色质重塑。
Epigenetic mechanisms, including DNA methylation, histone modification and chromatin remodeling, have been demonstrated to be involved in the development of SLE.
靶向DNA甲基化和组蛋白去乙酰化酶的几个表观药物已经在临床试验中被测试。
Several epigenetic drugs targeting DNA methylation and histone deacetylation enzymes have been tested in clinical trials.
抑制性标记由3个甲基基团组成，结合到组蛋白H4的一个赖氨酸残基上。
The repressive mark was composed of three methyl groups attached to a lysine on the H4 histone.
随着组蛋白赖氨酸去甲基化酶的发现，证实组蛋白赖氨酸甲基化是一个可以逆转的组蛋白表遗传修饰。
The discovery of the histone lysine demethylases has strongly demonstrated that histone lysine methylation is a reversible epigenetic modification.
活化的差异组蛋白修饰标记物对抑制基因的改变伴随着这些DNA甲基化改变。
Differential histone modification marks of active versus repressed genes accompany these DNA methylation changes.
SDS - PAGE、圆二色谱和MALDI - TOF质谱分析结果表明，成功获得纯度较高的重组蛋白，且具有去甲基化的活性。
Results of SDS-PAGE, CD and MALDI-TOF showed that the recombinant protein was obtained successfully with high purity and possessed demethylation activity.
表观遗传变异对于植物的生长发育起着重要作用，主要包括DNA甲基化、组蛋白修饰、染色体重塑和RNA干涉等。
Epigenetic variation plays an important role in plant growth and development, including DNA methylation, histone modification, chromosome remodeling, and RNA interference and so on.
“我们实验室制作适当甲基化的均质组蛋白的能力对与晶体学是必需的，”Shokat说。
"The ability of our laboratory to make homogeneous histones with the appropriate methylation was essential for the crystallography," said Shokat.
甲基化作为一个调控组蛋白的机制现在已经研究的比较透彻，但其它的蛋白也有同样的调控机制却很少见。
With histones, methylation is well recognized as a regulatory mechanism, but the fact that other proteins are also be modified in the same way is a relatively new observation.
植物基因组的功能依赖于染色质标记，诸如dna的甲基化和组蛋白的转录后修饰。
The function of plant genomes depends on chromatin marks such as the methylation of DNA and the post-translational modification of histones.
表遗传学机制在肺癌的形成中占据重要地位，包括DNA的甲基化和组蛋白修饰，肺癌中与癌形成有关基因的失活多与异常甲基化有关，并且组蛋白修饰和甲基化紧密联系着。
Aberrant methylation may be the most common mechanism of inactivating cancer-related genes in lung cancer, and histone modification may be closely associated with DNA methylation.
基因沉默的这种状态与D1基因启动子中的组蛋白甲基化和DNA甲基化修饰受抑制有关，而不涉及DNA序列的改变。
The silenced state is correlated with repressive histone and DNA methylation marks in the D1 promoter region but is not associated with DNA sequence alterations.
此外，两种同步化处理均导致组蛋白H3K9甲基化和H3K4单甲基化表达下降，但不影响组蛋白H3K4三甲基化的表达水平。
In addition, both serum starvation and DMSO treatment reduced the histone H3K4 single-methylation and H3K9 methylation, but H3K4 triple-methylation was not changed.
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