组蛋白乙酰化促进基因表达，而去乙酰化则抑制基因表达。
Histone acetylation contributes to expression of gene, while histone deacetylation leads to repression of gene expression.
组蛋白乙酰化修饰与基因的表达调控相关，参与了各种肺部疾病的病变过程。
The acetylation of histone is related to gene expression and regulation, which takes part in the pathological courses of all kinds of lung diseases.
组蛋白乙酰化和去乙酰化可以改变染色质的结构，参与基因的表达调控和重编程。
Histone acetylation and de-acetylation can change the structure of chromatin, involving in gene expression regulation and nuclear reprogramming.
组蛋白乙酰化和去乙酰化可调节染色体的多种功能，例如基因表达和染色体分离等。
Histone acetylation and deacetylation can regulate many chromosome functions, such as gene expression and chromosome segregation.
如同阿尔茨海默病鼠，增强组蛋白乙酰化的药物改善了年老小鼠在认知测试中的表现。
As in the Alzheimer's mice, drugs that boosted histone acetylation improved the older mice's performance on tests of rodent cognition.
我们认为姜黄素的抗肿瘤作用，与其HAT抑制活性及对组蛋白乙酰化的诱导作用关系不大。
We believe that the effect of HAT inhibition and induction of histone hyperacetylation of curcumin plays little role in its anti-cancer effect.
目的观察dna甲基化和组蛋白乙酰化对人结肠癌细胞系癌相关基因的表达和细胞周期的影响。
Purpose to investigate the effects of DNA methylation and histone acetylation on the expression of tumor associated genes and cell cycle progression in human colonic cancer cells.
组蛋白乙酰化与基因转录等生物效应有密切的关系，组蛋白乙酰化主要是由组蛋白乙酸转移酶催化的。
Histone acetylation has a close relation with some biological effects such as gene transcription, and is catalyzed by histone acetyltransferases.
其他的工作集中在组蛋白乙酰化，这种化学修饰可以使DNA从组蛋白缠绕中解离出来，产生基因活性。
Other work has focused on histone acetylation, a chemical modification that unwinds DNA from protein spools called histones, thereby enabling gene activity.
组蛋白乙酰化和去乙酰化由一对功能相互拮抗的蛋白酶——组蛋白乙酰基转移酶和组蛋白去乙酰化酶负责。
The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other, which are histone transacetylase and histone deacetylase.
结论P 38MAPK信号通路可能通过上调组蛋白乙酰化水平增加SH - SY5Y的APP蛋白表达。
Conclusion APP expression on SH-SY5Y cells may increase through up-regulation of histone acetylation through P38MAPK pathway.
高脂肪组产的子鼠的葡萄糖代谢基因有些表观改变，组蛋白乙酰化环节——能打开DNA环使基因转录更容易——是其中一处改变。
The high-fat offspring also had epigenetic modifications to genes that regulate glucose metabolism.
组蛋白脱乙酰基酶与组蛋白脱乙酰基酶抑制剂通过对组蛋白乙酰化水平的调控，影响特定基因的表达，改变细胞周期的进程。
HDAC and histone deacetylase inhibitors (HDI) can affect expression of some specific genes and induce cell differentiation growth arrest and apoptosis through regulating histone acetylation level.
下面的视频是关于在癌症细胞里的常规基因表达是如何进行组蛋白乙酰化作用(acetylationofhistone)的。
Here's a video that animates the acetylation of histone proteins in the regulation of gene expression in cancer cells.
在2007年5月10日的自然杂志中，他们报道了一种促进组蛋白乙酰化的药物，它能增强阿耳茨海默氏病模型老鼠的学习和记忆能力。
In the 10 May 2007 issue of Nature, they reported that a drug that promotes histone acetylation improved learning and memory in a mouse model of Alzheimer's disease.
乙酰化反应使组蛋白让DNA解螺旋，允许了基因的表达发生，因此抑制乙酰化反应将从总体上降低基因的表达。
Acetylation causes histones to unspool their DNA, thereby allowing gene expression to proceed—so decreased acetylation generally reduces gene expression.
人们很早就注意到，真核细胞中核小体核心组蛋白N-端尾部的乙酰化水平与基因活化密切相关。
It has been known for some time that the acetylation of N-termini of core histones in nucleosome is associated with gene activation.
组蛋白尾端不同的化学修饰往往和基因的表达调控有着密切的关系，乙酰化就是常见的一种修饰形式。
Gene expression is often closely related to the different chemical modification ends of protein, acetylation is a kind of common form of modification.
组蛋白乙酰转移酶和组蛋白去乙酰酶活性共同决定了组蛋白的乙酰化水平。
The level of his-tone acetylation is determined by the activities of histone acetyltransferases and histone deacetylases.
研究表明，组蛋白的乙酰化与去乙酰化状态，可作用于T、B细胞的发育、分化、成熟、分泌及表面因子的表达等多个方面。
Studies had shown that acetylation and deacetylation of histone are of certain value on t, B cell's development, differentiation, maturation, secretion and surface factor's expression etc.
主要探讨组蛋白共价修饰中乙酰化和甲基化在消化道肿瘤形成过程中的作用。
This review focuses on how aberrant covalent histone modifications such as acetylation and methylation may contribute to the development of alimentary canal neoplasms.
他们发现，大脑中有一个“开关”控制瘦素的作用，它就是一种名为组蛋白去乙酰化酶5（HDAC5）的酶。
They have discovered an enzyme - histone deacetylase 5 (HDAC5) - has a significant influence on the effect of the hormone.
组蛋白去乙酰酶抑制剂可提高组蛋白的乙酰化水平，并对一些非组蛋白成分产生影响，从而调节某些特定基因的表达。
Histone deacetylase inhibitors increase the acetylation level of histone as well as some non-histone proteins, and specifically modulate some gene expression.
目的：探讨组蛋白去乙酰化酶抑制剂MS- 275诱导人多发性骨髓瘤细胞株u266凋亡的分子机制。
OBJECTIVE: to investigate the molecular mechanisms of histone deacetylase inhibitor MS-275 on apoptosis of human myeloma U266 cell line.
本研究是对推测的小麦组蛋白乙酰转移酶及脱乙酰化酶基因功能研究的首次报道。
This is a first report about function study of histone acetyltransferase and deacetylase in wheat.
靶向DNA甲基化和组蛋白去乙酰化酶的几个表观药物已经在临床试验中被测试。
Several epigenetic drugs targeting DNA methylation and histone deacetylation enzymes have been tested in clinical trials.
本文主要就组蛋白乙酰转移酶调节基因转录以及组蛋白去乙酰化酶抑制剂促进记忆形成的作用机理进行综述。
In this paper, we reviewed the mechanisms on histone acetyltransferases regulating gene transcription and histone deacetylase inhibitors promoting memory formation.
认识到开发新颖治疗剂的要求，本发明提供新颖组蛋白去乙酰化酶抑制剂。
In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors.
本文综述了丁酸和植物提取物等饲料添加剂作为组蛋白去乙酰化酶(HDAC)抑制剂在模型动物及畜禽上的研究进展。
This review focused on the advances of the effect of feed additives, such as butyrate and plant extracts, on model animal and livestock as inhibitors of histone deacetylases (HDAC).
抗肿瘤药罗米地辛是一种有效的组蛋白去乙酰化酶抑制剂，临床 上用于治疗皮肤T细胞淋巴瘤。
Romidepsin is a potent histone deacetylase inhibitor, and is used in the treatment of cutaneous T-cell lymphoma (CTCL).
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