在此论文中阐述了这些因子对破骨细胞的分化和功能具有重要作用。

Here we show that these three factors have critical roles in osteoclast differentiation and function.

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目的探讨白三烯（LT）B4能否不依赖细胞核因子资B受体激活剂配体（RANKL）直接促进人破骨细胞的分化和激活。

Objective To determine whether leukotriene B4 (LTB4) could directly stimulate human osteoclast differentiation and activation independent of RANKL (ODF).

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一旦由包括VEGF在内的促成熟细胞因子活化后，破骨细胞的前体细胞可以分化成为成熟的破骨细胞，破坏骨组织，给肿瘤细胞的生长腾出空间。

When activated by maturation factors including VEGF, the pre-osteoclasts differentiated into mature osteoclasts and chew up bone tissue, providing the tumor new space to grow.

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一旦由包括VEGF在内的促成熟细胞因子活化后，破骨细胞的前体细胞可以分化成为成熟的破骨细胞，破坏骨组织，给肿瘤细胞的生长腾出空间。

When activated by maturation factors including VEGF, the pre-osteoclasts differentiated into mature osteoclasts and chew up bone tissue, providing the tumor new space to grow.

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