抑制因子的整体结构与阻遏物蛋白的相比变化不大。
The overall structure of the repressor is little changed from that of the aporepressor.
一组称为多梳抑制复合物1（PRC1）蛋白质沉默基因必须先结合到特定的组蛋白上的甲基化位点。
A group of proteins called the polycomb repressive complex 1 (PRC1) that silences genes must first bind to a particular methylated address on a histone and.
基本的单链多肽，通过与酶的活性位点紧密结合形成复合物，抑制大多数的丝氨酸蛋白酶。
Basic single-chain polypeptide that inhibits numerous serine proteases by binding to the active site of the enzyme, forming tight complexes.
目的：探讨兔髂动脉球囊剥脱术后局部灌注重组组织因子途径抑制物蛋白对血管内膜增生的抑制作用。
AIM to investigate the inhibitory effect of local perfusion of recombinant tissue factor pathway inhibitor protein on intima hyperplasia in atherosclerotic arteries after balloon stripping in rabbits.
目的研究基质金属蛋白酶- 9 (MMP - 9)和基质金属蛋白酶抑制物- 1 (TIMP - 1)在早孕期蜕膜和绒毛中的表达特点。
Objective to study the expression of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) proteins in the decidua and villi of the early pregnancy.
这些被抑制和被激活的蛋白可能为肿瘤生物标志物和药物作用靶点，为肿瘤的诊断和治疗提供了新的候选蛋白。
These repressed or activated proteins were the potential tumor biomarkers and drug targets, which would offer the candidate proteins for tumor diagnosis and treatments.
金属蛋白酶抑制剂，含有它们的药物组合物和其药物用途，其制备方法和中间体。
Metalloproteinase inhibitors, pharmaceutical compositions containing the same and their pharmaceutical USES, and methods and intermediates useful for their preparation.
向细胞裂解液中加入蛋白酶抑制剂后可以保护细胞提取物中的靶蛋白。
The addition of protease inhibitors to the cell lysis buffer AIDS in the preservation of target proteins in the cell extract.
豆浆不煮熟煮透，所含的胰蛋白酶抑制物未被破坏，不仅豆浆难以消化，还会引起恶心、呕吐和腹泻。
Cook soy milk is not cooked, contained in trypsin inhibitors have not been destroyed, not only difficult to digest soy milk, but also cause nausea, vomiting and diarrhea.
黄酮类化合物对P糖蛋白外泵作用的抑制效果越来越引起人们的关注。
Inhibitory effects of the flavonoid derivatives on P-glycoprotein (P-gp) -mediated drug efflux have attracted more and more interest of researchers.
目的探讨大蹼铃蟾蛋白提取物对膀胱癌细胞株的抑制作用及对端粒酶的影响。
AIM To study the boosting effect of Bombina maxima protein on bladder cancer cell lines growth and expression of telomerase.
有实验证明花生米红衣提取物能抑制纤维蛋白的溶解，促进血小板新生及毛细血管收缩，实现止血。
Trials show the extract from peanut's scarlet can withhold fibrinolysis and speed up the processes of microvascular constriction and production of blood plaque.
金属蛋白酶抑制剂，含有它们的药物组合物和其药物用途，其制备方法和中间体。
Inhibitors of metalloproteinase, pharmaceutical compositions containing them, their pharmaceutical application and methods and intermediate compounds for their preparation.
结论千里光的抗金黄色葡萄球菌作用机制可能是通过抑制细菌的DNA,RNA，蛋白质和肽聚糖的合成有关，其作用的有效成分可能是黄酮类化合物。
ConclusionThe antibacterial mechanism of SSB on S. aureus may be involved with the inhibition of DNA, RNA, protein and peptidoglycan synthesis, its effective ingredients may be flavonoid compound.
纤溶酶原激活物抑制物1 (PAI - 1)是血浆纤维蛋白溶解系统的重要组成物之一，对维持血浆纤溶系统的稳定起重要作用。
Plasminogen activator inhibitor-1 (PAI-1) is one of the important components of the plasma fibrinolytic system and plays an key role in maintaining its stability.
研究结果表明：玉米蛋白粉类胡萝卜素提取物叶黄素和玉米黄素具有明显抑制口腔上皮癌细胞增殖、并诱导其凋亡的作用。
This paper suggested that the carotenoids—lutein and zeaxanthin existed in corn gluten meal had the potential function of inducing KB cell apoptosis.
藤黄含有一种生物活性化合物，已知这种物质能够抑制血脂及脂肪酸的合成，并降低低密度脂蛋白和甘油三酯的形成。
Garcnia Cambogia contains a biologically active compound which is known to inhibit the synthesis of lipids and fatty acids and lower the formation of LDL and triglycerides.
综述了有机硼酸类化合物作为酶抑制剂的研究进展，重点介绍了近年来发现的丝氨酸蛋白酶抑制剂、蛋白酶体抑制剂和精氨酸酶抑制剂。
The recent progress of boronic acid derivatives used as enzyme inhibitors is reviewed focused on the serine protease inhibitors, proteasome inhibitors, and arginase inhibitors.
目的研究基质金属蛋白酶-2（MMP-2）及其抑制物组织基质金属蛋白酶抑制剂-2（TIMP-2）在大肠癌进展中的作用及其临床意义。
Purpose To understand the relationship between the expression of MMP-2, TIMP-2 and the clinical significance in human colorectal carcinoma.
其原因在于存在于合成物表面的PEG链能起到防护层的作用，进而抑制了由于非特异性蛋白质的吸附而引起的聚集反应。
This was attributed to the PEG chains present on the surface of complexes that could work as a protective shield layer against aggregation caused by non-specific protein adsorption.
活化的差异组蛋白修饰标记物对抑制基因的改变伴随着这些DNA甲基化改变。
Differential histone modification marks of active versus repressed genes accompany these DNA methylation changes.
本文综述了丁酸和植物提取物等饲料添加剂作为组蛋白去乙酰化酶(HDAC)抑制剂在模型动物及畜禽上的研究进展。
This review focused on the advances of the effect of feed additives, such as butyrate and plant extracts, on model animal and livestock as inhibitors of histone deacetylases (HDAC).
基质金属蛋白酶的组织特异性抑制物是一组多功能基因家族，它们能特异性地抑制基质金属蛋白酶。
The tissue inhibitor of metalloproteinases (TIMPs) are a large family of multi-functional genes, and they specifically inhibit MMPs.
本发明中的溴酚类化合物具有蛋白质酪氨酸磷酸酯酶(PTP1B)抑制活性，可用于治疗2型糖尿病和肥胖症。
The bromophenol compounds of the invention have inhibitory activity against protein tyrosine phosphatase (PTP1B), and can be used for treating the type 2 diabetes and the obesity.
本发明还涉及含有结构式(I)的天冬氨酸蛋白酶抑制剂的药物组合物。
The present invention is also directed to pharmaceutical compositions comprising the aspartic protease inhibitors of Structural Formula (I).
用作蛋白激酶抑制剂的2，5和2，6双取代的氮茚类似物。
5- and 2,6-disubstituted benzazole analogues useful as protein kinase inhibitors.
细胞渗透、有效的蛋白磷酸酶抑制剂。凋亡诱导剂。两种异构体的混合物。
Cell permeable, potent protein phosphatase inhibitor. Apoptosis inducer. Mixture of two isomers.
本发明公开了新的具有HCV蛋白酶抑制活性的大环化合物以及制备这些化合物的方法。
The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds.
线粒体中的抑制素主要以膜结合环复合物的形式存在且在蛋白合成和转运过程中作为分子伴侣维持线粒体蛋白的稳定性(3,4)。
In mitochondria prohibitins mainly exist as membrane-bound ring complexes and function as chaperones maintaining mitochondrial protein stability during protein synthesis and transportation (3, 4).
本发明涉及可用作蛋白激酶、特别是JAK家族激酶的抑制剂的式(i)化合物。
The present invention relates to compounds of formula (I) useful as inhibitors of protein kinases, particularly of JAK family kinases.
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