1983年美国食品药品管理局批准丙戊酸钠用于癫痫发作，VPA也在各种神经精神疾病上用作心境稳定剂，包括与痴呆症相关的兴奋。
Approved by the us Food and Drug Administration in 1983 for epileptic seizures, VPA is also used as a mood stabilizer in various neuropsychiatric conditions, including dementia-related agitation.
双丙戊酸钠ER的处方信息长达28页；拉莫三嗪58页。
The prescribing information for Depakote ER is 28 pages long; for Lamictal, 58 pages.
我们没有观察到利培酮合用锂盐或丙戊酸钠的不良反应，尽管在丙戊酸钠上血浆浓度峰值增加20%。
No effects of risperidone on lithium or valproate exposure were observed, despite a 20% increase in valproate peak plasma concentration.
暴露在丙戊酸钠下具有比其他抗癫痫药更高的出生缺陷，比如卡马西平和拉莫三秦。
That valproate exposure carries a higher risk of birth defectsthan other antiepileptics, such as lamotrigine and carbamazepine, is not new knowledge, Torbjorn Tomson, M.D.
另外，“对丙戊酸钠的风险讨论应当与不可控制的疾病突发风险的考虑相平衡，”Tomson建议到。
In addition, "discussion of the risks ofvalproate should be balanced with consideration of the risksof uncontrolled seizures," Tomson recommended.
目的：研究丙戊酸钠对血浆纤维蛋白原的影响。
ABSTRACT Objective: To study the influence of sodium valproate on plasma fibrinogen.
如果使用拉莫三嗪的同时使用了丙戊酸钠或双丙戊酸钠，或者采用了更高的起始剂量，或是增加剂量速度过快都有可能增加发生皮疹的风险。
The risk of developing a rash is higher if taking lamotrigine while also taking valproate or divalproex sodium or if taking a higher starting dose or increasing the dose faster than prescribed.
结论：本检测方法快速、灵敏、经济，可用于监测人血清中丙戊酸钠的浓度。
CONCLUSION: This HPLC-fluorescence method is quick, sensitive and economical, which can be used to monitor the concentration of sodium valproate in human serum.
目的：比较丙戊酸钠栓剂与片剂的药代动力学特征。
Objective: to compared the pharmacokinetics of sodium valproate suppository with sodium valproate tablets.
结论冰片可提高血脑屏障对丙戊酸钠的通透性，但对血药浓度影响较小。
ConclusionBorneol can enhance the permeability of blood-brain barrier to sodium valproate, but has small influence on blood concentration.
目的：通过对坐骨神经损伤模型的药物实验研究，观察丙戊酸钠对大鼠周围神经损伤的修复作用。
AIM: To observe the effects of sodium valproate in the repair of rat sciatic nerve injury through the drug experiment of the model of sciatic nerve injury.
丙戊酸钠作为常用一线抗癫痫药，目前在临床的应用较为广泛。
As a first - line agent for treating epilepsy, valproate sodium is widely used in clinic.
目的：评价丙戊酸钠与卡马西平对锂盐治疗无效的躁狂发作的疗效和副反应。
Objective: to evaluate the efficacy and side effects of sodium valproate and carbamazepine in the treatment of manic episodes refractory to lithium carbonate.
目的探讨丙戊酸钠对酒精戒断反应的临床疗效及副反应。
Objective To investigate the clinical efficacy and side effects of sodium valproate in the treatment of alcohol withdrawal reaction.
目的抗癫痫药物可以引起甲状腺激素水平改变，本研究旨在探讨抗癫痫药卡马西平(CBZ)、丙戊酸钠(VPA)对男性癫痫病人甲状腺激素水平的影响。
Objective: Antiepileptic drugs (AEDS) may affect serum thyroid hormone concentration. this study aimed to evaluate thyroid function in men taking carbamazepine (CBZ), or valproate (VPA) for epilepsy.
丙戊酸钠和卡马西平是强有力的肝酶诱导剂，使丙戊酸钠血浓度降低。
PTH and CBZ are potent inducers of hepatic enzyme and can lower the serum concentration of VPA.
前言：目的：探讨影响丙戊酸钠血药浓度波动的因素，提高丙戊酸钠血药浓度检测的有效性及可利用性。
OBJECTIVE: to observe the factors that influence the fluctuation of serum concentrations of valproic acid and to improve the effectiveness and usefulness of monitoring the serum concentration.
特别是丙戊酸钠对突触可塑性影响的报道很少，结果也不一致。
So far, there were few studies about effects of VPA on synaptic transmission and the data presented were not consistent.
结论：在癫痫的病程和丙戊酸钠治疗中，血清fsh的浓度升高，其机制可能与疾病和药物的共同作用有关。
Conclusion: During the disease course and VPA therapy of epilepsy, the serum concentration of FSH is ascending. The mechanism might be the interaction of both the disease and the drug.
方法：采用荧光偏振免疫法对2 6例服用苯妥英钠、74例服用卡马西平、14 4例服用丙戊酸钠的患者血药浓度监测结果及临床疗效分析、评价。
Method: The serum concentration of oral phenytoin, carbamazepine and valproic acid were determined in 26,74 and 144 epileptic patients by fluorescence polarization immunoassay, respectively.
方法：采用荧光偏振免疫法对2 6例服用苯妥英钠、74例服用卡马西平、14 4例服用丙戊酸钠的患者血药浓度监测结果及临床疗效分析、评价。
Method: The serum concentration of oral phenytoin, carbamazepine and valproic acid were determined in 26,74 and 144 epileptic patients by fluorescence polarization immunoassay, respectively.
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