结论：人类肥胖的发生可能与瘦素抵抗而不是瘦素缺乏有关。
Conclusion: Obesity in humans may be due to leptin resistance rather than to leptin deficiency.
然而后来的研究发现，肥胖的人并不缺乏足够的瘦素。其原因尚不完全清楚，但他们存在瘦素抵抗。
But later research found that obese people don't lack sufficient leptin. For reasons not fully understood, their cells are resistant to it.
瘦素抵抗、血清高瘦素浓度等病理状态时，瘦素可能影响前脂肪细胞的增殖及进一步分化为脂肪细胞，调节肥胖发生。
Leptin maybe regulate the generation of obesity through acting on the proliferation and differentiation of preadipocyte at the state of leptin resistance and high leptin concentration in serum.
但是他们的身体却对瘦素有极大的抗性，就如同第二型糖尿病患者抵抗胰岛素的作用一样。
They are resistant to the effects of leptin in much the same way that people with type 2 diabetes are resistant to the effects of insulin.
目的探讨肥胖2型糖尿病患者胰岛素抵抗与瘦素、血浆抵抗素、血脂、骨代谢的变化及相关性。
Objective To investigate the relationship and changes between insulin resistance and serum resistin, leptin, lipid, and bone metabolism in type 2 diabetic patients with obesity.
结论：瘦素和糖尿病之间的关联是通过胰岛素抵抗介导的。
CONCLUSIONS: The association between leptin and incident diabetes is mediated by insulin resistance.
结论老年COPD稳定期患者血清抵抗素水平下降，气流受限和瘦素分泌的减少与抵抗素水平的下降有关。
Conclusions the serum resistin level in COPD patients is decreased, which may be caused by air-flow limitation and the decrease of leptin secretion.
研究的主要作者科斯卡塔琳博士补充说：“瘦素是脂肪细胞产生用来调节食欲的，但肥胖患者的身体抵抗这种减少食欲的作用。”
Dr Katarina Kos, lead author of the research, added: "Leptin is produced in fat cells to regulate appetite, but the body becomes resistant to the effects of appetite reduction in obese patients."
目的探讨瘦素-胰岛素抵抗对机械通气患者代谢的影响。
Objective To investigate the effects of leptin-insulin resistance for the patients using mechanical ventilation.
瘦素水平与体脂分布和胰岛素抵抗密切相关，与血脂水平未显相关性。
The distribution of body fat and insulin resistence, but not serum cholesterol and triglyceride, are closely correlated with fasting leptin level.
瘦素与肝硬化患者的胰岛素抵抗相关。
通过从体型瘦、正常糖耐受者的软脂酸盐治疗肌管，从胰岛素抵抗者的肌肉组织中检测到再次产生TLR4含量和表达的升高现象。
Increased TLR4 content and gene expression observed in muscle from insulin-resistant subjects were reproduced by treating myotubes from lean, normal-glucose-tolerant subjects with palmitate.
胰岛素抵抗与瘦素水平显著正相关。
There were positive correlations between insulin resistance and leptin levels.
目的：研究男性冠心病与瘦素、胰岛素抵抗之间的关系，评价瘦素在男性冠心病发病中的作用。
Objective: To assess the role of leptin in the pathogenesis of coronary heart disease (CHD) in men and the relationship among serum leptin, insulin resistance and coronary heart disease (CHD) in men.
与非血瘀证组比较，血瘀证组瘦素、内皮素、肿瘤坏死因子水平升高，脂联素、胰岛素水平降低，血清抵抗素差异无统计学意义。
Compared with the non-blood stasis syndrome group, the content of leptin, ET and TNF in the blood stasis syndrome group significantly raised, but the content of adiponectin and insulin diminished.
与非血瘀证组比较，血瘀证组瘦素、内皮素、肿瘤坏死因子水平升高，脂联素、胰岛素水平降低，血清抵抗素差异无统计学意义。
Compared with the non-blood stasis syndrome group, the content of leptin, ET and TNF in the blood stasis syndrome group significantly raised, but the content of adiponectin and insulin diminished.
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