追踪甲基化的能力因而在科学上有其重要性。
The ability to track methylation is thus scientifically important.
主要研究dna甲基化的生物信息学分析。
人们特别关心那些在自然界能被甲基化的金属。
The metals which are of particular concern are those which have been shown to be methylated in nature.
很明显，DNA甲基化的严格调控对于正常发育是必需的。
It is clear that tight regulation of DNA methylation is necessary for normal development.
本研究发现从全序列水平来看，水稻胚乳DNA是去甲基化的。
Here, we show that rice endosperm DNA is hypomethylated in all sequence contexts.
实验结果表明，胶束催化是实现芳环化合物氯甲基化的有效方法。
The results show that the micellar catalysis is an effective way to realize the chloromethylation.
而且，甲基化的模式在DNA长链中被聚集到一起，显示了与早期环境相关的后天模式。
Moreover, the methylation patterns were clustered together in large swaths of DNA, suggesting an epigenetic pattern linked to humans’ early environments.
在某些情况下，甲基化的酶作用物能够从隐马尔科夫模型序列相似性网络中被推断。
In some cases, the substrate of methylation can be inferred from hidden Markov model sequence similarity networks.
发生DNA甲基化的MDS患者EZH2表达水平高于未发生DNA甲基化的患者。
The MDS patients with DNA methylation had higher EZH2 expression than those without DNA methylation.
随着患者临床分期和组织学分级的增加，FHIT基因甲基化的检出率也在逐渐的增加。
We found a strong positive correlation between FHIT methylation in the plasma and the clinical stage and histological grade of the tumor.
背景：许多癌症中已发现DNA甲基化的存在，并以此作为生物标志物用于诊断和分型了。
Background: DNA methylation biomarkers capable of diagnosis and subtyping have been found for many cancers.
介绍了聚苯乙烯树脂间接氯甲基化的方法。对影响氯甲基化反应的一些条件、因素作了讨论。
The methods about indirect Chloromethylation of Polystyrene are discussed, and the conditions and factors affecting the reactions of chloro - methylation also discussed here.
“我们实验室制作适当甲基化的均质组蛋白的能力对与晶体学是必需的，”Shokat说。
"The ability of our laboratory to make homogeneous histones with the appropriate methylation was essential for the crystallography," said Shokat.
过去甲基化的结构研究被阻碍的原因是因为很难制备组蛋白特定部位赖氨酸甲基化的均一样品。
Past structural studies of methylation were hindered by the extreme difficulty of constructing homogeneous samples of histones bearing methyl groups attached to specific lysine residues.
研究发现，孕期中遭到虐待的母亲生下糖皮质激素受体基因被甲基化的幼儿的可能性要比其他母亲高出得多。
They found that women abused during pregnancy were significantly more likely than others to have a child with methylated glucocorticoid-receptor genes.
我们的研究提供了与人类肿瘤异常基因沉默相关的异常DNA甲基化的动态过程的另一种认识。
Our findings provide additional insight for the dynamics of aberrant DNA methylation associated with aberrant gene silencing in human tumors.
禾谷类作物提供了人类决大部分的营养，但是谷类植物种子甲基化的全局动态变化还不是很清楚。
Global methylation dynamics in seeds of cereal crops that provide the bulk of human nutrition remain unknown.
与对照相比，经超低温保存的样品新产生的甲基化位点有14个，而去甲基化的位点有22个。
Compared to the control, 14 sites showed denovo methylation, and 22 sites were demethylated in the samples after cryopreservation.
但是Shokat和他的同事已经在实验室合成了一种化学物质，它的结构可以模拟甲基化的赖氨酸。
However, Shokat and his colleagues had synthesized a chemical structure in the lab that mimics lysine with the methyl groups attached.
至于哪个更可能是原因他并没能做出预测，但是他说许多东西如基因突变也能导致甲基化的缺陷，这也可能导致不育。
He didn't speculate as to which is the more likely culprit, but said that many things, such as gene mutations, could cause defects in methylation that might result in infertility.
但是甲基化的发生模式会随着我们年龄的增加发生变化，这也就为通过测定甲基化确定人体年龄提供了可能。
But the patterns of methylation change as we grow older. Which was a clue that measuring methylation might give away age.
如果你观察普通人群，调查多少比例的人有[胰岛素类生长因子2基因编码甲基化的缺陷]，大概是百分之5。
If you look in the normal population and ask what fraction of people have [a defect in methylation in the gene encoding insulin-like growth factor 2] it's about 5 percent.
在DNA甲基化的胞嘧啶碱基在许多真核生物的表观遗传调控提供了一层正常的生物学和疾病有着重要的意义。
Methylation of cytosine bases in DNA provides a layer of epigenetic control in many eukaryotes that has important implications for normal biology and disease.
他们的团队对一组10到19岁的儿童进行了糖皮质激素受体基因甲基化的检测，并对他们的妈妈做了同样的检测。
Their team examined the methylation of the glucocorticoid-receptor gene in a group of children ranging in age from ten to 19 years, and in those children's mothers.
DNA甲基化变化频率递减的顺序依次是：V27、V14、R 09； V27品系显现出更多的去甲基化的位点。
Frequencies of decrease in DNA methylation sites among cultivars were in this order: V27, V14, and R09, V27 showing more demethylation sites.
它依赖于用亚硫酸氢钠处理后，非甲基化的 胞嘧啶选择性的去氨基为 尿嘧啶，通常接着所选的靶向区域的PCR扩增。
It relies upon the selective deamination of unmethylated cytosine to uracil after treatment with sodium bisulphite, usually followed by PCR amplification of the chosen target region.
他们选择的对象既有生活水平非常高的也有非常低的，并且，他们覆盖了其中的20000个基因来观察dna甲基化的差异。
They chose subjects that had come from either very high or very low standards of living, and they looked at differences in DNA methylation across some 20, 000 genes.
他们选择的对象既有生活水平非常高的也有非常低的，并且，他们覆盖了其中的20000个基因来观察dna甲基化的差异。
They chose subjects that had come from either very high or very low standards of living, and they looked at differences in DNA methylation across some 20, 000 genes.
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