如果这些区域变成甲基化，它往往压制有关的基因转录。
If these areas become methylated, it tends to suppress transcription of the gene in question.
未来可以深入研究某种甲基化差异和具体疾病的关系，然后针对那些区域用药治疗。
Future research could peg where certain methylation differences are associated with specific diseases, then target those areas with drugs or other treatments.
斯维特研究小组最近发现，小鼠的电击空间关联训练降低其海马区DNA甲基化，而海马区是脑部记忆形成的重要区域。
Sweatt's team recently discovered that training mice to associate a certain location with a mild electric shock reduced DNA methylation in the hippocampus, a brain region crucial for memory formation.
在启动子区域的DNA甲基化是抑制基因活性的一种重要机制。
DNA methylation in the promoter regions is a powerful mechanism for the suppression of gene activity.
广泛的低甲基化和区域性高甲基化是基因异常表达的常见机制。
Global hypomethylation and regional hypermethylation are common mechanisms of aberrant expression of gene.
这种现象主要在印迹基因和X染色体失活区域看到，这些区域中的启动子区的DNA甲基化导致了基因表达的抑制。
This phenomenon is mostly seen in imprinted genes and X-chromosome inactivation where DNA methylation of promoter regions leads to repression of gene expression.
它依赖于用亚硫酸氢钠处理后，非甲基化的 胞嘧啶选择性的去氨基为 尿嘧啶，通常接着所选的靶向区域的PCR扩增。
It relies upon the selective deamination of unmethylated cytosine to uracil after treatment with sodium bisulphite, usually followed by PCR amplification of the chosen target region.
通常情况下，基因表达水平与DNA甲基化呈负相关，基因启动子区域甲基化从而导致该基因沉默。
Under usual conditions, there is an inverse correlation between gene expression level and DNA methylation. The gene can be silenced by DNA promoter methylation.
通常情况下，基因表达水平与DNA甲基化呈负相关，基因启动子区域甲基化从而导致该基因沉默。
Under usual conditions, there is an inverse correlation between gene expression level and DNA methylation. The gene can be silenced by DNA promoter methylation.
应用推荐