苯并咪唑盐是本课题组提出的四氢叶酸辅酶的新模型。
Benzimidazolium salt as a new tetrahydrofolate coenzyme model was introduced.
四氢叶酸辅酶模型1,2,3 -三取代咪唑啉盐的质谱裂解行为。
Tetrahydrofolate Coenzyme Models. The Mass Spectrometric Analysis of 1, 2, 3 Trisubstituted Imidazolinium Salts.
该方法已用于设计抑制剂大肠杆菌二氢叶酸还原酶和人类磷脂酶a2。
This method has been applied to the design of inhibitors for E. coli dihydrofolate reductase and human phospholipase A2.
四氢叶酸（THF）辅酶是生物合成与细胞代谢的过程中一碳单元转移的载体。
Tetrahydrofolate(THF) cofactor is the carrier of one-carbon unit on biosynthesis and cell metabolize.
结论亚甲基四氢叶酸还原酶基因C677T基因多态性可能是我国大肠癌的遗传易感因素。
Conclusion These findings demonstrated that the genetic variation of MTHFR C677T should be a genetic susceptibility factor for colorectal cancer in a Chinese population.
该文就近年来亚甲基四氢叶酸还原酶基因多态性与高危妊娠和胎儿畸形关系做一简要综述。
In this review, we summarized researches on the correlation between methylenetetrahydroflate reductase gene polymorphism, high-risk pregnancy and congenital anomalies.
目的观察应用草酸铂联合氟尿嘧啶、甲酰四氢叶酸治疗晚期大肠癌的客观疗效及不良反应。
To observe the efficacy and toxicity of combination chemotherapy with HCPT/CF/5Fu in advanced colorectal cancer.
目的探讨北方乡村妇女亚甲基四氢叶酸还原酶（MTHFR）基因多态性与神经管畸形的关系。
Objective To explore relationship between methylenetetra hydrofolate reductase (MTHFR) polymorphism and neural tube defects (NTDs)of women in the northern countryside.
提示用叶酸或甲酰四氢叶酸钙后能保护复方硝喹对小肠的破坏，因而会大大减轻其临床毒性反应。
The results suggest that folic acid or folinic acid can protect the less differentiated cells in the intestinal crypts, so that the clinical manifestations of NQD toxicity are reduced after treatment.
亚甲基四氢叶酸还原酶基因突变导致的遗传多态现象可增加神经管缺陷(ntd)发生的危险性。
The genetic polymorphisms due to mutations in the methylene tetrahydrofolate reductase gene may increase the risk for NTDs.
建立了一种采用毛细管电泳法(CE)测定二氢叶酸还原酶(DHFR)反应动力学参数的新方法。
A novel screening method for dihydrofolate reductase inhibitors (DHFRI) using high performance capillary electrophoresis (HPCE) was developed.
抗叶酸类抗疟药的抗药性机制已基本搞清，与其作用靶酶二氢叶酸还原酶或二氢蝶酸合成酶基因点突变相关。
The molecular mechanism of resistance to the antifolates has been well characterisied and is due to structural changes in the target enzymes resulting from the point mutations of DHFR or DHPS gene.
目的探讨不同剂量四氢叶酸钙(CF)对大剂量甲氨蝶呤(HD -MTX)化疗大鼠肠黏膜的保护作用。
Objective To explore different doses of calcium 5-formyltetrahydrofolate (CF) for protecting enteral mucosa after chemotherapy of high-dose methotrexate (HD-MTX) in rats.
结论：进行甲氨蝶呤血药浓度监测有利于掌握好甲氨蝶呤和四氢叶酸钙的救援剂量，从而保证化疗的有效性和安全性。
CONCLUSIONS: MTX serum concentration monitoring is helpful for mastering the rational rescue dosage of MTX and calcium folinate so as to ensure the efficacy and safety of the chemotherapy.
治疗组病人应用ddp、HCFU化疗，对照组应用ddp、氟尿嘧啶(FU)、醛氢叶酸(CF)化疗，评价两组疗效和毒性反应。
The treatment group received DDP and HCFU, and the control group was given DDP, fluorouracil (FU), calcium folinate (CF). The efficacy and toxicity were evaluated.
目的建立一种简便、实用的检测亚甲基四氢叶酸还原酶(MTHFR)等位基因C677 T点突变的方法，并初步观察部分健康老人和老年血管性痴呆(VD)患者中mthfr等位基因C677 T点突变情况。
Objective to establish a simple and practical method for detecting the MTHFR gene C677T mutation so as to investigate MTHFR genotypes in the healthy elder and Vascular Dementia (VD).
目的建立一种简便、实用的检测亚甲基四氢叶酸还原酶(MTHFR)等位基因C677 T点突变的方法，并初步观察部分健康老人和老年血管性痴呆(VD)患者中mthfr等位基因C677 T点突变情况。
Objective to establish a simple and practical method for detecting the MTHFR gene C677T mutation so as to investigate MTHFR genotypes in the healthy elder and Vascular Dementia (VD).
应用推荐