设计药物的研制,必将建立在以疾病过程中受损的分子途径为主要目标的基因组方法基础上。
The development of designer drugs will be based on a genomic approach to targeting molecular pathways that are disrupted in disease.
草雀唱歌的行为改变了歌曲控制中心超过800处的基因表达,期中包括了一个可以改变他们转录因子和其目标的基因。
Singing changes expression for over 800 genes in the song control center, including ones that alter the expression of transcription factors and their targets.
然而,人们有了大脑,人们可以思考到达新目标的途径——这是由进化塑造的而不是由基因决定的。
However, since we've inherited big brains, we can now think our way to new goals-shaped by evolution but not determined by it.
也许你可以这样看待这个问题,基因是随机有目标的射击,而不是基因轰炸。
You might think of it as a targeted shotgun of randomness instead of a bomb of it.
一个给定系统,比如,一个基因编码一种酶,一个志向的工程功能标的,如催化的交易额,是判断的。
A given system, for example, a gene encoding an enzyme, and a desired engineering performance goal, such as catalytic turnover, are identified.
创造环境监测和环境污染净化为目标的新型植物将成为转基因植物研究的极其重要的研究方向之一。
To culture new-typed plants for environment monitoring and environment purifying will become one of the most important research fields in for transgenic plant research.
结论FHIT和WWOX基因系重要的候选抑瘤基因,与其他预后指标的联合检测可望对患者的治疗预后作出更准确的预测。
Conclusions FHIT and WWOX are candidate tumor suppressor genes. Detected coordinately with other (molecular) parameters, they can make the prognosis of therapy more accurate to predict.
本试验研究了高赖氨酸转基因水稻替代40%、100%玉米作为能量饲料对肉仔鸡屠宰及血液生化指标的影响。
The effect of high lysine transgenic paddy instead of 40 %, 100 % corn as energy feed on broiler slaughter performance and blood biochemical indicators were studied.
这种疾病是遗传所致,但是通常只在带有致病遗传基因同时也体重超标的人才会患这种疾病。
The disease is genetic, but often develops only when someone who has the genes for it also becomes overweight.
所有这些基因都负责熟知的药品(诸如抗抑郁药、精神抑制药与包括百忧解、舒马曲坦与安理申等在内的止疼片)的分子靶标的编码。
The genes all encode molecular targets of well-known pharmaceuticals, such as antidepressants, antipsychotics and pain relievers including Prozac, Imitrex, and Aricept.
结果与临床常规方法相比,耐药检测基因芯片鉴定指标的灵敏度均>96%,特异度均>98%;
Results The sensitivity of all identification indexes of DNA chip were higher than 96%, and all of their specificity were higher than 98%.
目的通过检测上皮膜抗原(EMA)、表皮糖蛋白基因(EGP - 2)在乳腺癌组织中的表达,分析它们与乳腺癌临床病理指标的关系,并研究两者表达的相关性。
Objective to investigate the expression of EMA and EGP-2 in breast carcinoma tissues, to analyze their relationship with clinical indexes and to observe the correlation with their expression.
由于基因组学已经成为寻找新出击目标的跳板,因而大开抗病毒新药的发现之门。
Genomics has been a springboard for discovering fresh targets for attack and has thus opened the way to development of whole new classes of antiviral drugs.
现对化学基因组学研究的典型方法,以及对基于药物作用靶标的分子设计的影响作一介绍。
This article introduces the typical methods of chemogenomics research and its effect on molecular designing in view of target.
研究人员曾经认为主控转录因子通过直接调节许多基因来产生广泛的影响,但事实上具有最多直接的调节靶标的转录因子处于这种层次网络的中间。
Finally, one might think master TFs achieve their wide influence through directly regulating many targets, but TFs with most direct targets are in the middle of the hierarchy.
基因治疗技术引入牙周病治疗的研究领域,为这一目标的实现带来了新的希望。
Now, gene therapy technique has been introduced into the field of periodontology as a new hope to reach the target.
小鼠基因组数据库(MGD)集成鼠标的遗传和基因组数据,以方便使用鼠标作为一个模型系统,为了解人类生物学和疾病的进程。
The Mouse Genome Database (MGD) integrates genetic and genomic data for the mouse in order to facilitate the use of the mouse as a model system for understanding human biology and disease processes.
摘要本试验旨在研究甘露聚糖酶转基因玉米对肉鸡生长性能、屠宰性能及血清生理生化指标的影响。
Abstract: This experiment was conducted to investigate the effects of mannanase transgenic corn on growth performance, carcass performance and blood physiological and biochemical indexes of broilers.
通过直接将量子位的Bloch坐标视为基因位,提出一种基于量子位Bloch坐标的量子衍生进化算法。
By directly regarding the Bloch coordinates of qubit as genes in chromosome, a quantum-inspired evolution algorithm is proposed.
筛选准药物分子作用标的之平台技术与癌症基因晶片。
The platform technology for drugs and lead screening and the cancer diagnostic biochips.
筛选准药物分子作用标的之平台技术与癌症基因晶片。
The platform technology for drugs and lead screening and the cancer diagnostic biochips.
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