这种药物有一个很大的限制因素，其药效只能持续6个小时。
This drug has one important limitation. Its effects only last six hours.
然而，仍然有一个很大的障碍。
这里有一个很大的障碍。
因为我会说日语，所以我有一个很大的优势。
左侧有一个很大的“GETSNORT ”链接，就在那只大鼻子猪的下方。
There's a large "GET SNORT" link on the left, just under the pig with a big nose.
在申请这一职位的其他候选人相比，我有一个很大的优势就是我曾经在瑞士学习过。
Comparing with many other candidates for the position, I have a great advantage which is I have studied in Switzerland.
维持友谊。现在在这个世界上，有一个很大的趋势把你移到一边或另一边，并处于冲突中。
Maintain friendships. In this world right now, there is a great tendency to move you to one side or the other, and be in conflict.
我发现他有一个很大的可取之处。
总体上看，有一个很大的一代人的转变，与自己的父母相比，第二代父母更不可能打屁股。
Overall, there was a large generational shift in which the second generation of parents was much less likely to spank than their own parents.
尤其是测试过程有一个很大的成功。
这个技巧有一个很大的优点。
有一个很大的，挡住了视线。
但是有一个很大的问题。
这样做有一个很大的弊端：浏览器兼容性。
他们有一个很大的成功与这一点。
我们有一个很大的特性集，叫做“游戏规则”。
实验证明是有一个很大的撞击效应产生。
房间里有一个很大的壁橱，你可以把你的行李放进去。
位于西秀区的山脊上，有一个很大的烽火台。
Located on the Xixiu Ridge (the West Embroidery Ridge) of the Lishan Mountain, the remains of the beacon tower of the Western Zhou Dynasty seem easy to identify.
如果你已经有一个很大的水瓶了，把它给亲戚或朋友。
And if you already have a bulky reusable water bottle give it to a family member or friend.
不幸的是，较短的路线有一个很大的缺点：它是单行道。
Unfortunately the short route has a major shortcoming: it is one-way.
从进化的观点来看，永生不灭的生命有一个很大的缺点。
Eternal life, from an evolutionary standpoint, however, has a big drawback.
版本3有一个很大的缺点：它使一个类与特定的方面关联在一起。
That version suffered from one major drawback: it tied a class to particular aspects.
我们在花园里有一个很大的水池，但他们却有一个巨大的湖！
We have a large pool in the garden, but those guys have a huge lake!
这句话的意思是：在美国，垒球和橄榄球有一个很大的区别。
There is one big difference between baseball and football in America.
还有就是大学，SantaBarbara有一个很大的社区大学。
But much of the local economy is recession-proof. As well as the university, Santa Barbara has a large community college.
还有就是大学，SantaBarbara有一个很大的社区大学。
But much of the local economy is recession-proof. As well as the university, Santa Barbara has a large community college.
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