但什么是这些药物的最佳剂量，最大耐受剂量，最大限度抑制目标的最小剂量？
The maximum tolerated dose? The minimum dose that leads to maximum inhibition of the target?
本文综述关于I期临床试验的研究。主要介绍确定最大耐受剂量（MTD）的不同方法，以及提出可以进一步进行研究的问题。
This paper summarizes studies for phase I clinical trials. It mainly introduces different, methods about determining maximum tolerated dose(MTD) and proposes further subjects for future research.
这篇论文主要研究的是第i阶段临床试验中最大耐受剂量的估计问题。
In this paper, the estimation of the maximum tolerated dose of a drug for phase I clinical trials is investigated.
主要介绍确定最大耐受剂量(MTD)的不同方法，以及提出可以进一步进行研究的问题。
It mainly introduces different, methods about determining maximum tolerated dose (MTD) and proposes further subjects for future research.
本文研究的是在第一阶段临床试验中，寻找两种制剂混合而成药物的最大耐受剂量的方法。
In this paper, the author want to probe the method how to find one or more acceptable drug dose combinations of two agents used together in a Phase I clinical trial.
本文研究的是药物最大耐受剂量（MTD）的识别方法。
The paper investigates designs of dose-finding trials, the purpose of which is to determine the maximum tolerated dose (MTD).
结果防晕船口服液基本无毒性，抗晕船口服液小鼠最大耐受剂量为临床剂量的100倍以上。
Results Prevent-sick syrup was nontoxic. The mice maximum tolerance of anti-seasickness oral solution was 100 times higher than that of clinical dosage.
观察小鼠一日内给予大剂量钙纳米粒子的急性中毒及死亡情况，得出半数致死量（LD50）或最大耐受量（MTD）。
To observe the acute toxicity and death of the mice to which calcium nanoparticles were given in maximal dose and obtain the lethal dose 50(LD50) or the maximal tolerance dose (MTD).
急性毒性实验结果表明，利咽颗粒剂毒性很小，小鼠一次最大耐受为临床人用剂量的850倍。
The acute toxicity test showed that the maximal tolerable dose in rats was equivalent to 850 times of the clinical dosage in human.
急性毒性实验结果表明，利咽颗粒剂毒性很小，小鼠一次最大耐受为临床人用剂量的850倍。
The acute toxicity test showed that the maximal tolerable dose in rats was equivalent to 850 times of the clinical dosage in human.
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