例如，“患者服用小于最佳疗效剂量的抗精神病药物后可能变得更不依从。”
For example, “patients with a less than optimal response to an antipsychotic medication might be more likely to become nonadherent.”
但什么是这些药物的最佳剂量，最大耐受剂量，最大限度抑制目标的最小剂量？
The maximum tolerated dose? The minimum dose that leads to maximum inhibition of the target?
目的：探讨分娩镇痛的最佳方法及药物剂量。
Objective: To explore the best method and medication dosage.
目的临床观察不同剂量美百乐镇降脂作用，选择疗效确切安全地美百乐镇降脂的最佳药物剂量。
Objective To observe the decreasing blood lipid action with varied dosage of mevalotin and select the best dosage with safe effect.
我们正在规划一个寻找最佳剂量和证明药物的有效性的关键性试验。
We are now in the process of planning a dose finding pivotal trial to optimize the dosing regime and demonstrate the efficacy of the drug.
结论：精准药学服务可有效地为患者提供最佳的给药方案，预测初始治疗剂量及最佳治疗浓度，提高药物治疗效果、减少药品不良反应。
CONCLUSIONS: Precision pharmaceutical care can effectively provide patients with optimal dosing regimens, predict initial dose and optimal therapeutic concentrations, improve efficacy and reduce ADR.
但是所有这些药物都面临毒副作用大，患者耐受性差，用药剂量很难达到最佳治疗剂量，而且最重要的是有效率较低。
However all these drugs used now have great toxic side effect, bad tolerance so it's hard to reach optimal therapeutic dosage, and what's more the response rate is low.
有没有有效的药效学上的生物标记的代替物能够对决定某个药物的最佳剂量？
Are there clinically useful markers that can predict the efficacy of this class of drug?
有没有有效的药效学上的生物标记的代替物能够对决定某个药物的最佳剂量？
Are there clinically useful markers that can predict the efficacy of this class of drug?
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