由美国食品与药品管理局批准治疗转移克隆癌的贝伐单抗,是血管内皮生长因子的单克隆抗体。
Bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor, is approved by the US Food and Drug Administration for metastatic colon cancer.
目的:在众多血管再生性因子中,血管内皮生长因子及其受体2是公认的促使血管生成的关键性因素。
OBJECTIVE Vascular endothelial growth factor VEGF and its receptor 2 are the generally accepted key factor on the formation of blood vessel in numerous blood vessel regeneration factors.
采用化学治疗药物(贝伐单抗,是中和血管内皮生长因子的人源化抗体)治疗可导致蛋白尿和肾功能损害。
Treatment with the chemotherapeutic agent bevacizumab, a humanized mab that neutralizes vascular endothelial growth factor, can lead to proteinuria and renal damage.
然而在众多的血管生成因子中,血管内皮细胞生长因子(VEGF)是最有力的血管生成因子。
But in many vascular growth factors, vascular endothelial cell growth factor (VEGF) is the most important vascular growth factor.
目的:血管内皮生长因子(VEGF)也称血管渗透因子,是一种重要的血管生成因子,主要由血管内皮细胞产生。
Objective: vascular endothelial growth factor (VEGF) also is named vascular permeability factor, which is one of the important angiogenesis factors and mainly produced by vascular endothelial cells.
血管内皮生长因子(VEGF)是目前发现的最强有力的血管形成因子。
Vascular endothelial growth factor (VEGF) has been found to be the most powerful angiogenic factor.
结论:骨髓间质干细胞在大鼠心脏内可以转化为血管内皮细胞或分泌血管内皮生长因子,是治疗缺血性心血管疾病理想的细胞来源。
CONCLUSION: MSCs can be transformed into vascular endothelial cells or secrete VEGF in rat hearts, thus is the ideal cell source of therapy in ischemic cardiovascular disease.
新生血管大量形成在实体瘤的生长和转移中起着关键的作用。血管内皮生长因子(VEGF)是介导肿瘤血管生成的最主要因素。
New vessel formation plays a key role in tumor growth and transforming, and the Vascular endothelial growth factor (VEGF) is the most important factor inducing tumor vessel formation.
第1个模型是通过注射了血管内皮生长因子的抗体,或者可溶性的血管内皮生长因子受体1,从而获得的。
The first model is generated by injection of antibodies to vascular endothelial growth factor or soluble vascular endothelial growth factor receptor 1.
血管内皮生长因子是促进血管生成的重要调节因子。
Vascular endothelial growth factor VEGF plays a central role in tumor angiogenesis.
结论:缺氧可以上调小鼠肺组织中的血管内皮生长因子,引起血管新生,但它可能是可逆的。
CONCLUSION: Hypoxia can up-regulate the expression of VEGF in the lung tissue of mice and plays an important role in angiogenesis, and the change might be reversible.
血管内皮生长因子(VEGF)是一类能促进血管生成的细胞因子,能诱导细胞的有丝分裂和调节内皮细胞的通透性。
The vascular endothelial growth factor (VEGF) is a kind of potent angiogenic cytokine that induces mitosis and regulates the permeability of endothelial cells.
血管内皮生长因子是促进血管生成的重要调节因子。
Vascular endothelial growth factor (VEGF) plays a central role in tumor angiogenesis.
此外,它似乎一种表达的时间当然是在分析的重要,虽然没有定量的EGFP或血管内皮生长因子。
Also, it seems that a time course of expression was important in the analysis although no quantitation was provided for the EGFP or the VEGF.
血管内皮生长因子和色素上皮细胞衍生因子是目前发现的作用最强的角膜新生血管形成促进因子和抑制因子。
Vascular endothelial growth factor and pigment epithelium-derived factor are most enhancing factor and strongest inhibitory factor of corneal neovascularization(CNV)at present.
血管内皮生长因子(VEGF)可能是涉及的主要因素之一,但可能不是唯一的一个。
Vascular endothelial growth factor (VEGF) is probably one of the main factors involved but perhaps not the only one.
血管内皮生长因子是重要的血管生成因子,可调节内皮增殖、血管生成、调节血管通透性及血栓形成。
VEGF is an important angiogenesis factor, which can regulate endothelial proliferation, angiogenesis, permeability of blood vessel, thrombogenesis.
血管内皮生长因子是一种多功能的细胞因子,参与机体多种生理、病理过程。
Vascular endothelial growth factor (VEGF) is a multi-effective cytokine, which participates many physiological and pathological processes.
血管内皮生长因子(VEGF)是目前所知的作用最强的促血管生成因子之一,它可以直接或间接地参与血管生成的每个环节。
Vascular endothelial growth factor (VEGF) is one of the most powerful pro-angiogenesis factor at present, which can participate in each link of the angiogenesis directly or indirectly.
目的:肿瘤血管生成是肿瘤生长和侵袭的基础,血管内皮细胞生长因子(VEGF)是最重要的血管生成因子,在许多人类肿瘤均可检测到了这种因子。
Objective: Angiogenesis of tumor is the base of tumor growth and invasion. Vascular endothelial growth factor (VEGF) is the most potent angiogenesis factor and has been detected in many human tumours.
血管内皮生长因子是目前所知唯一作用于血管内皮的生长因子,在血管发生中处枢纽地位。
Vascular endothelial growth factor is only one endothelium specific growth factor that plays a pivotal role in angiogenesis.
血管内皮生长因子- A (VEGF - A)最近被认为是在中枢神经系统中一种重要的神经护卫。
Vascular endothelial growth factor-A (VEGF-A) has recently been recognized as an important neuroprotectant in the central nervous system.
贝伐单抗阻断血管内皮生长因子(VEGF)受体活性,是肿瘤血管生成,增殖和转移的重要因子。
Bevacizumab blocks the action of the vascular endothelial growth factor (VEGF) receptor, a key factor in tumor angiogenesis, growth, and metastasis.
使用特定药理学制剂如抗氧化剂和PKC抑制剂,靶向血管内皮生长因子表达可能证明对治疗糖尿病性视网膜病变是有效的。
Targeting VEGF expression with specific pharmacological agents, such as antioxidants and PKC inhibitors, may prove efficacious for the treatment of diabetic retinopathy.
目的:血管内皮生长因子C(VEGF-C)属于血管内皮生长因子(VEGF)家族成员,被认为是目前发现的唯一特异性淋巴管生成因子。
Objective:Vascular endothelial growth factor C(VEGF-C) recently has been identified as a new member of the VEGF family and is considered as the single specific lymphangiogenic factor.
目的:血管内皮生长因子C(VEGF-C)属于血管内皮生长因子(VEGF)家族成员,被认为是目前发现的唯一特异性淋巴管生成因子。
Objective:Vascular endothelial growth factor C(VEGF-C) recently has been identified as a new member of the VEGF family and is considered as the single specific lymphangiogenic factor.
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