结论：角蛋白9基因的G485A突变是导致该家系发生弥漫性掌跖角化病的原因。
Conclusion the mutation G485A found in keratin 9 gene is the disease-causing mutation in the diffuse palmoplantar keratoderma family.
本文回顾性分析了阿维A酯治疗91例角化性皮肤病（银屑病、毛发红糠疹、掌跖角化病等）的疗效和不良反应。
The effect and adverse drug reactions(ADRs )of etretinate in 91patients with keratinization, including psoriasis, pityriasis rubra pilaris, ichthyosis were analyzed retrospectively.
主要表现为色素脱失、色素沉着及掌跖过度角化，具此三联症者72例（7．35％）。
The main manifestation was hypopigment, hyperpigment, and palmoplantar Hyperkeratosis. Triad cases happened in 72 patients (7.35%).
本文报告了一例罕见的遗传性掌跖皮肤角化病—遗传性残毁性角化瘤，并与各种掌跖皮肤角化症、断肢症的鉴别进行了讨论。
This paper is reported a rare case of palmoplanter keratoma hereditaria-keratoma hereditaria mutilans and differential diagnosis with various palmoplantar keratodermas and dactylolysis are discussed.
本文报告了一例罕见的遗传性掌跖皮肤角化病—遗传性残毁性角化瘤，并与各种掌跖皮肤角化症、断肢症的鉴别进行了讨论。
This paper is reported a rare case of palmoplanter keratoma hereditaria-keratoma hereditaria mutilans and differential diagnosis with various palmoplantar keratodermas and dactylolysis are discussed.
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