目的：探讨表皮生长因子受体(EGFR)基因酪氨酸激酶域体细胞在肺腺癌患者中突变的相关因素。
Objective: to study Somatic mutation of the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR gene) in lung adenocarcinoma patients.
方法：对原发性高血压伴胰岛素抵抗患者胰岛素受体基因酪氨酸激酶域外显子17、18基因突变进行检测，并对突变的外显子进行核苷酸序列分析。
Methods: Using PCR SSCP, we detected the mutation of INSR tyrosine kinase domain exon 17 and exon 18 in 33 primary hypertension patients and 28 normal persons.
结论：NURR1基因结合神经干细胞有效改善了帕金森病模型症状，提高移植后酪氨酸羟化酶阳性神经元细胞的数量。
CONCLUSION: NURR1 gene combined with NSC can effectively ameliorate PD models symptoms and elevate the number of tyrosine hydroxylase positive neurons after transplantation.
BCR -ABL融合基因表达出的酪氨酸激酶能引起细胞增殖、黏附和生存性质的改变，导致多种肿瘤的产生。
The tyrosine kinases expressed by BCR-ABL fusion gene can cause cell proliferation, adhesion and survival natural change, several kinds of tumors can be caused by it.
目的观察瘦素对大鼠肝细胞瘦素受体蛋白、基因表达及酪氨酸磷酸化的影响。
Objective to investigate effects of leptin on gene and protein expression and tyrosine phosphorylation of leptin receptor in rat hepatocytes.
获取人蛋白酪氨酸磷酸酯酶4A2（PTP4A2）基因并高效表达纯化，对于产物的体外活性进行测定。
To obtain human protein tyrosine phosphatase type 4A2 (PTP4A2) gene expressed in E. coli and purify the target proteins.
目的：研究散发型甲状腺髓样癌酪氨酸激酶受体基因（RET）的突变情况。
Objective:To explore the mutation of receptor tyrosine kinase ( RET ) gene in sporadic medullary thyroid carcinoma.
这些观察提示突变的酪氨酸磷酸酶是肿瘤抑制基因，它调节的细胞通路可能会被利用到治疗干预中去。
These observations suggest that the mutated tyrosine phosphatases are tumor suppressor genes, regulating cellular pathways that may be amenable to therapeutic intervention.
第三部分酪氨酸酶基因克隆。
目的：探讨结直肠癌细胞中脾酪氨酸激酶基因甲基化和表达的关系。
AIM: To explore the relationship of methylation status and expression of spleen tyrosine kinase (Syk) gene in colorectal cancer cell lines.
例如，结果从一个白化突变失活的基因称为酪氨酸酶，这是至关重要的黑色色素的形成。
For example, albinism results from a mutation that inactivates a gene called tyrosinase, which is vital to black pigment formation.
酪氨酸修饰剂的作用引起酶活力下降，初步证明，组氨酸残基是该酶活力的必需基因。
Modifying reagents of tyrosine caused remarkable decrease in the enzyme activity. And histidyl-residues were essential groups for enzyme activity.
本文报道了在克隆了小鼠酪氨酸酶基因的基础上，在大肠杆菌表达体系中诱导表达野生型和变异型酪氨酸酶的结果。
Here we reported the cloning of the gene from murine tyrosinase, the expression of wild tyrosinase and variants in E. coli.
目的观察瘦素对大鼠肝细胞瘦素受体蛋白、基因表达及酪氨酸磷酸化的影响。
The role of adhesion moleculesinduced tyrosine phosphorylation proteins in procollagen expression in fibroblasts;
是第一个被定义为癌基因的酪氨酸磷酸酶。
It is the first tyrosine phosphatase that was defined as the oncogene.
是第一个被定义为癌基因的酪氨酸磷酸酶。
It is the first tyrosine phosphatase that was defined as the oncogene.
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