滴丸制剂是一种固体分散体。
不同的固体分散体制备方法对药物的溶出度影响不大。
Preparation methods had little effect on the dissolution rates of daidzein solid dispersion.
他克莫司在固体分散体中可能以无定型态或分子状态存在。
Tacrolimus existed as amorphous or molecular state in tacrolimus solid dispersions.
结论依托度酸固体分散体能显著提高依托度酸的溶出速率。
Conclusion Etodolac solid dispersion can significantly increase the dissolution rate.
目的:制备尼群地平固体分散体,增加其溶解度和溶出速度。
OBJECTIVE To improve the solubility and dissolution of nitrendipine by preparing its solid dispersions.
目的:制备卡维地洛固体分散体,提高其溶解度和溶速率。
OBJECTIVE: To improve the dissolubility and dissolution rate of carvedilol.
结果:固体分散体能加快药物的溶出速率,最佳比例为1∶7。
Results: The in vitro dissolution rates of ISDN solid dispersion were faster than ISDN.
最终筛选出了合适的处方,并制备出了较为理想的固体分散体。
We ultimately selected the suitable diclazuril solid dispersions prescription and technology, and prepared ideal diclazuril solid dispersions.
制得的坎地沙坦固体分散体为一稳定体系,具有实际应用价值。
Candesartan SD is a stabilizing system which having actual applied value.
热差分析及粉末X衍射结果表明固体分散体中槲皮素呈非结晶形式;
The results of DSC and PXRD showed that the quercetin in solid dispersion was amorphous form.
PEG葛根黄酮固体分散体中,借分子中的·OH形成更多的氢键。
The PEG RP isoflavones solid dispersions formed more hydro-keys resulted by -oh in the molecules.
结果各种固体分散体均能大大增加他克莫司的溶解度,加快其体外溶出。
RESULTS The solubility and in vitro dissolution of all tacrolimus solid dispersions were increased significantly.
目的 将难溶性药物阿德福韦酯制备成固体分散体,以增加体外溶出度。
Objective To prepare adefovir dipivoxil solid dispersion from poorly-soluble adefovir dipivoxil so as to improve its dissolution rate in vitro.
结论:伊曲康唑固体分散体能明显提高伊曲康唑的溶解度及体外溶出速率。
CONCLUSION Itraconazole solid dispersion can significantly increase it's solubility and dissolution rate.
目的:利用固体分散技术制备阿西美辛固体分散体,增加其溶解度和溶出速度。
OBJECTIVE To improve in vitro release of acemetacin, the technology of solid dispersion was used and acemetacin was prepared as solid dispersion.
目的:利用固体分散技术制备替硝唑固体分散体,增加替硝唑溶解度和溶出速度。
OBJECTIVE: to prepare tinidazole solid dispersion using the technology of solid dispersion, and to increase the dissolubility and the dissolution rate of tinidazole.
方法以聚乙二醇6000为载体,溶剂-熔融法制备sud - 35固体分散体。
METHODS Solid dispersions of SUD-35 were prepared by solvent-fusion method with PEG6000 as carrier.
药物从固体分散体中的溶出度比原药粉末显著提高,且随着PVP比例的增加而增大。
The dissolution rate of CyA was increased dramatically after the formation of solid dispersion compared with the pure drug powder. CONCLUSION PVP can enhance the dissolution rate of CyA dramatically.
结果该固体分散体微丸对温度和湿度稳定,对光不稳定,模拟上市包装后稳定性良好。
Results The pellets were stable when exposed to high temperature and high humidity, but sensitive to light.
该制剂的制备采用了超临界提取及絮凝醇沉的工艺及环糊精包埋与固体分散体制剂技术。
It is prepared by supercritical extraction, flocculating and alcohol settling cyclodextrin investing and solid dispersion preparation technique.
目的优化葛根素磷脂复合物的制备工艺,研究其固体分散体,提高葛根素的体外溶出速率。
OBJECTIVE to optimize preparation techniques for puerarin phytosomes and explore their solid dispersions to increase the dissolution of puerarin in vitro.
方法:采用溶剂法制备固体分散体,进行溶解度、溶出速率测定,导数热重分析(DTG)。
Methods: the solid dispersion was prepared by solvent method. The solubility, the dissolution rate and the derivative thermogravimetry (DTG) were determined.
方法:将冰片用水溶性辅料聚乙二醇6000制成固体分散体,并填装入胶囊,进行毒理试验。
Method: Bomeolum Syntheticum and PEG 6000 mixing preparative solid dispersion and packed capsules, toxicity was tested.
结论PVP固体分散体可有效提高姜黄素的溶解性,同时应用在治疗胃溃疡具有很好的开发前景。
CONCLUSION The solid dispersion in PVP k30 improves the solubility of curcumin. These findings show a potential application of curcumin SDs as an anti-ulcerogenic drug.
结论:拉曼光谱法快速、直接、对样品无损伤,是一种新的理想的检查固体分散体分散性的方法。
Conclusion: Raman spectrometry which is fast, direct and non-destructive is an ideal method in examining the dispersivity of solid dispersion.
结论:拉曼光谱法快速、直接、对样品无损伤,是一种新的理想的检查固体分散体分散性的方法。
Conclusion: Raman spectrometry which is fast, direct and non-destructive is an ideal method for examining the dispersivity of solid dispersion.
结论:拉曼光谱法快速、直接、对样品无损伤,是一种新的理想的检查固体分散体分散性的方法。
Conclusion: Raman spectrometry which is fast, direct and non-destructive is an ideal method for examining the dispersivity of solid dispersion.
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