丝氨酸蛋白酶和乙酰胆碱酯酶高效的不可逆抑制剂。
A potent irreversible inhibitor of serine proteases and acetyl choline esterase.
不可逆抑制剂紧密结合的酶形成基本上是永久的复杂。
Irreversible inhibitors bind tightly to an enzyme to form an essentially permanent complex.
本文研究了DTNB对人肌肌酸激酶的不可逆抑制作用。
The irreversible inhibition of creatine kinase from human muscle during modification with DTNB has been studied.
酶学动力学研究表明，抑制包含可逆抑制和不可逆抑制两部分。
It was showed that the inhibition consisted of both reversible inhibition and irreversible inhibition through kinetics studies.
结果表明，熊果甙对酪氨酸酶活性的抑制作用表现为可逆抑制效应。
The results show that the inhibition of tyrosinase by arbutin is a reversible reaction with remaining enzyme activity.
结论氯乙醇对鼠肝线粒体钙泵的不可逆抑制作用可能与共价结合有关。
Conclusion the damage of CE on the calcium pump of mitochondria might be irreversible because of the formation of covalent binding of CE-target macromolecules.
不可逆抑制剂有两大类酶抑制剂，可逆和不可逆的，其酶的亲和力的大小有区别的。
Irreversible inhibitors There are two main classes of enzyme inhibitors, reversible and irreversible, that are differentiated by the magnitude of their affinity for enzyme.
有机磷农药生物传感器已有很多报道，其设计原理大多是基于乙酰胆碱酯酶的不可逆抑制作用。
The design theory of the organ phosphorus pesticide biosensor is based on the irreversible restrain of acetyl cholinesterase by the organ phosphorus pesticide.
不可逆抑制剂因为它们是永久删除其催化活性的酶，这种紧张复杂，也被称为不可逆抑制剂灭活。
Irreversible inhibitors Because they form such a tight complex with the enzyme that they permanently remove its catalytic activity, irreversible inhibitors are also termed inactivators.
凝血酶及其他丝氨酸蛋白酶的不可逆抑制剂，将活性位点酰基化。比PMSF和DF P毒性小得多。
Irreversible inhibitor of Thrombin and other serine proteases. Inhibits by acylation of the active site of the enzyme. Much less toxic than PMSF and DFP.
一些不可逆抑制剂，甚至成为共价结合的酶的活性部位的氨基酸，因为他们带来的是通过早期的催化化学步骤。
Some irreversible inhibitors even become covalently bound to amino acids in the active site of the enzyme as they are brought through the early chemical steps of catalysis.
抑制剂一般是小分子，他们不可逆转地结合在受体上阻碍其正常功能，而兴奋剂可以是小或大分子。
Antagonists tend to be small molecules that bind irreversibly to the receptor preventing its normal function, while agonists may be small or large molecules (e.g. peptide or protein hormones).
也许最常见的血小板功能缺陷是使用阿司匹林造成的不可逆的血栓素抑制(这是血小板聚集所必要的)。
Probably the most common platelet function defect is the irreversible inhibition of thromboxane (which is necessary for platelet aggregation) caused by aspirin administration.
缺血预处理的保护作用在VEGF-A抑制后可逆转。
The protective effect of ischemic preconditioning was reversed after VEGF-A inhibition.
PF4属于造血负性调控因子，它抑制造血细胞增殖，但是它的这种作用是可逆的。
PF4 is a negative regulator of hematopoiesis and can inhibit hematopoietic cell proliferation but this effect is reversible.
但这种抑制是可逆的。
金属蛋白酶可逆的抑制剂，无毒。
作者造成不可逆转的钾离子通道抑制剂，使表征这些谜物。
The authors create irreversible potassium channel inhibitors that enable characterization of these enigmatic complexes.
此快速抑制作用呈可逆性、浓度依赖性和非电压依赖性。
The rapid effect induced by corticosterone was reversible, concentration-dependent, and voltage-independent.
通过蛋白酶活性位点丝氨酸残基的磺酰化，不可逆的抑制丝氨酸蛋白酶。
Irreversibly inhibits serine proteases by sulfonylation of the serine residue in the active site of the protease.
结果发现：海马脑片缺氧早期突触功能出现可逆性抑制，与外源施加高浓度腺苷反应类同。
The results showed that acute anoxia led to the reversible inhibition of synaptic function, which is similar to the response to addition of high concentration of exogenous adenosine.
防治B炸药渗油、抑制其药柱尺寸不可逆长大、增强其力学性能和降低感度是B炸药改性研究的重要内容。
It is mainly concerned the modification of Composition B to control exudation, restrain irreversible size growth, enhance mechanical properties and decrease sensitivity.
加兰他敏是从雪片莲中提取的一种生物碱，具有可逆性胆碱酯酶抑制活性。
Galantamine is an alkaloid originally extracted from the bulbs of the plant Leucojum aestivum and shows reversible acetylcholinesterase(AChE) inhibitory activity.
结果：血竭剂量依赖地抑制单个DRG细胞电压门控性钠通道电流，高剂量的血竭抑制作用不可逆。
The inhibition effect was irreversible at high dosage. Conclusion: blood resin inhibits the voltage gated sodium channel currents, which may well provide some analgesic effects.
其抑制作用是可逆的，呈剂量依赖关系。
未发现不可逆骨髓抑制现象及肝功能受损。
No irreversible bone marrow depression and liver function injury was found.
经过系统药理学研究表明，该生物碱具有良好抗胆碱酯酶效应，从而可认为该生物碱系一种新结构类型的可逆性胆碱酯酶抑制剂。
The systematic pharmacological study shows that this alkaloid possesses good anticholinesterase effect, and therefore it is a new structure type of reversible acetylcholinesterase inhibitor.
药效学分析表明蛋白酶体抑制药的抑制作用有剂量依赖性和可逆性。
Pharmacodynamic assay has shown that inhibition of proteasome is dose dependent and reversible.
氯通道阻断剂atp和NPPB可逆性地抑制此电流，ATP的抑制作用在外向电流显著强于内向电流。
Chloride channel blockers, NPPB and ATP, inhibited the currents reversibly. Moreover, the inhibition of ATP on the outward currents was stronger than that on the inward currents.
可逆酶抑制剂的结合和游离与他们在平衡过程中的酶。
Reversible enzyme inhibitors bind and dissociate with their enzyme in a equilibrium process.
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