并且对亲核试剂的体积效应、溶剂效应对亲核性影响，底物上吸电子基团的数目、吸电子能力对亲电性的影响，以及亲核取代反应的发生部位受哪些因素影响进行探讨。
At the same time, discuss about the impact factor to nucleophilicity such as the number of attract electron group, ability of attract electron and the nucleophilic substitution reaction part.
人群中DNA存在多态性，与药物反应相关的基因多态性可能产生药物效应的个体差异，例如药物代谢酶、药物作用受体以及其它一些与疾病相关基因等。
Polymorphisms exist in human genomic DNA. And some polymorphisms such as metabolic enzymes, drug receptors, and some other genes correlated with diseases may affect the drug responsiveness.
随着人类基因组计划的进展，越来越多的基因多态性被发现，而基因多态性在药物效应和毒物反应中的作用有赖于其遗传学基础。
With the development of the "human genome project", more and more gene polymorphism has been found. In the medicament effect and poison reaction, the gene polymorphism will depend on the genetic base.
结果表明：当内源性提示有效性比例较低时，学障和正常儿童的提示效度效应均不明显； 当提示目标间隔时间较长时，外源性提示有效性对各组被试的反应时无显著影响；
The results happened to be that under the conditions of low endogenous cue predictivity and long SOAs of exogenous cue, no cue-validity effects was found in all groups;
结果表明：当内源性提示有效性比例较低时，学障和正常儿童的提示效度效应均不明显； 当提示目标间隔时间较长时，外源性提示有效性对各组被试的反应时无显著影响；
The results happened to be that under the conditions of low endogenous cue predictivity and long SOAs of exogenous cue, no cue-validity effects was found in all groups;
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