方法:单次给药后检测肝脏系数和血液生化指标,观察组织病理学变化。
METHODS: Changes of liver coefficient, serum biochemistry, and histopathology were detected after single dose.
无论是各周血糖水平的变化,还是单次给药实验、糖耐量实验,仙人掌粗多糖都有明显的降血糖作用。
Blood glucose levels were determined every week, the effect of single administration was monitored in the first week, and glucose tolerance was determined after three weeks.
减量重复给药后发现,随着第二次给药剂量减少,脑组织中药物浓度与血清药物浓度的比值下降至0.7,近似可接近单次给药后的比值。
In repeated dose decreasing group, the CZP concentration ratio in both brain and serum declined to 0.7 with the dose decrease, almost the same as that of single-dose group.
在所择剂量范围内硝苯地平-阿替洛尔复方单次、连续灌胃给药对自发性高血压大鼠均有明显降压作用。
In the range of our prescribed doses, nifedipine atenolol tablets had apparently antihypertensive effect on SHR rats administered whether once or continuously by gavage.
单次和多次给药可采用单次或多次给药法评估生物利用度。
Single vs. multiple doses: Bioavailability may be assessed after single or repetitive (multiple) dosing.
采用HPLC - MS测定人血浆中阿折地平浓度,并计算单次及多次给药后的药动学参数。
The azelnidipine concentration in plasma was determined by HPLC-MS and the pharmacokinetic parameters were calculated.
每个程序均有扼要的数学原理,用法,举例及程序清单,全部内容将在本学报陆续发表,本文报告线性一室模型单次静注及非经血管给药的两个程序。
Each program was appended by a brief mathematic principle, operation, example and a list of programs. The program for linear 1—compartment model was reported i…
每个程序均有扼要的数学原理,用法,举例及程序清单,全部内容将在本学报陆续发表,本文报告线性一室模型单次静注及非经血管给药的两个程序。
Each program was appended by a brief mathematic principle, operation, example and a list of programs. The program for linear 1—compartment model was reported i…
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