这些证据都提示该受体可能是重要的抗精神病药物作用靶点。
These lines of evidence implicate a role of this receptor as an important target for antipsychotic drugs.
目前，人们对白色念珠菌的研究主要集中在弄清其致病机理和发现新的药物作用靶点。
Recent studies on C. albicans have been focused on understanding its pathogenesis and on identifying therapeutic targets for the development of novel antifungal drugs.
本文根据药物作用靶点和机制，以上述几类药物为主，综述了目前AD的药物研究进展。
In this paper, we review the current status of the drug development for AD, and mainly discuss the above-mentioned drugs which are classified according to their therapeutic targets.
结果：作用靶点不同的反义寡核苷酸对KB - A - 1细胞生长的抑制能力不同。
Results: the abilities of antisense oligonucleotides to inhibit the cell growth of KB-A-1 mainly depended upon their targeted sequences selected.
另外，我们也特别列举了一大类的非癌基因证据，它们有时往往可以作为治疗肿瘤的药物作用靶点。
In particular, we present evidence for a large class of non-oncogenes that are essential for cancer cell survival and present attractive drug targets.
药物代谢酶、转运体及药物作用靶点存在着的基因多态性与药物疗效和毒性的个体差异有很大关系。
The genetic polymorphism of drug metabolizing enzyme, transporter and target greatly influence the individual difference of drug efficiency and toxicity.
抗菌机制研究表明：大环内酯抗生素的作用靶点位于50S亚基肽通道的出口处，紧邻肽酰转移酶中心。
The mechanism of macrolide's action indicates that the binding sites of macrolides are located inside the nascent peptide exit tunnel of the ribosomal 50S subunit near the peptidyl transferase center.
作为一种刺激信号，药物也能够在不同的微环境及病理状态下通过不同的作用靶点产生不同的治疗效果。
As a stimulatory signal, drug can also produce different therapeutic effects through the different targets according to different microenvironment and pathologic state.
对DNA的研究是生命科学研究中一个极其重要的方面，在药物筛选和药物设计中它是重要的作用靶点。
It is an important biological target in the drug screening and drug designing. Lots of anticancer drugs and antiviral drugs had effects on DNA.
近几年，人们发现了几种新的药物作用靶点，通过对这些新靶点的研究，有望开发出更安全有效的调脂药物。
Recently some new targets in the process of lipid metabolism were found, they may lead to the development of new drugs.
来自EMBL的一个研究团队开发了一种计算方法，通过比较药物的副作用来看看能否预测药物的作用靶点。
A team of EMBL researchers now developed a computational tool that compares side effects to test if they can predict common targets of drugs.
这些被抑制和被激活的蛋白可能为肿瘤生物标志物和药物作用靶点，为肿瘤的诊断和治疗提供了新的候选蛋白。
These repressed or activated proteins were the potential tumor biomarkers and drug targets, which would offer the candidate proteins for tumor diagnosis and treatments.
Ray表示：“这真是一个好事情，短肽的作用靶点恰好是一个非常保守的区域，非常有希望成为药物候选。”
"The really good thing is that it targets a very conserved area," says Ray. "it does seem to be a promising candidate."
随着对糖尿病发病机制研究的深入，糖尿病药物研究也从对传统机制的药物研究过渡到对具有新作用靶点和新作用机制的药物研究。
With the advance of the pathogenesis of diabetes research, the study of diabetes drugs has transformed from the traditional antidiabetic drugs to the drugs which have new targets and new mechanism.
结论甲氨喋呤减少软骨破坏和骨质侵蚀，而养气血祛风湿方只减少骨质侵蚀，说明甲氨喋呤与养气血祛风湿方抗炎作用靶点有差异。
Conclusion MTX can alleviate the damage of cartilage and bone erosion, and YQXQFSR can alleviate bone erosion. The mechanisms of MTX and YQXQFSR on the treatment of rheumatoid arthritis are different.
本文以风湿性疾病常用的治疗药物为主线，归纳了近年来影响药物疗效中有关药物代谢酶、药物转运体和药物作用靶点的基因组学研究进展。
The progress of pharmacogenomic research in the effects of drug treatment on rheumatic diseases could prevent adverse reactions, and provide reasonable guidance to clinical treatment.
这一治疗方案能够防止HIV 病毒耐药株的产生，减少单一作用靶点药物的用药剂量和降低相应的毒性，最终治愈AIDS相关的病理学变化。
This approach could prevent the development of drug-resistant HIV strains and decrease the dosage and related toxicity of each single drug and lead to a cure for AIDS-associated pathologies.
酪氨酸蛋白磷酸酯酶1 B在胰岛素依赖的信号传导途径中发挥着非常重要的作用，并作为一个潜在的治疗2型糖尿病和肥胖的作用靶点日益受到广泛的关注。
PTP1B plays a very important role in the insulin-dependent signaling cascade and has attracted considerable attention as a possible target for the treatment of type 2 diabetes and obesity.
磷脂酸(phosphatidicacid,PA)是植物中重要的细胞内信号分子，被称为“脂质第二信使”，特别是几个PA的作用靶点已被克隆和鉴定。
Phosphatidic acid (PA) is an important intracellular signal molecule and is called the lipid second messenger because several targets of PA have especially been cloned and identified.
研究者认为：肌氨酸对肿瘤的转移有促进作用而且是未来潜在开发新药的靶点。
The research suggests that sarcosine plays a role in helping cancer to spread, and may be a potential target for future new drugs.
本文写作目的主要是复习1 -磷酸鞘氨醇的生物学特性和分布，及其在类风湿关节炎发病中的作用，进而讨论它作为类风湿关节炎治疗靶点的可能性。
The aim of this article was to review the biology and distribution of S1P, together with its role in ra, and to discuss its potential as a therapeutic target for ra.
柯西奥期待这些文章能够促使研究关注于对胆固醇对眼睛的作用问题上，这可以帮助科学家确定潜在的药物靶点。
Curcio anticipates that these papers will prompt more research aimed at understanding the role of cholesterol in the eye, which could help scientists identify potential drug targets.
血管内皮细胞生长因子(VEGF)及其受体在肿瘤血管新生中起重要作用，阻断VEGF的生成已成为抗肿瘤治疗的新靶点。
Vascular endothelial growth factor (VEGF) and its receptor play a critical role in tumor-associated angiogenesis and have become the new targets of anti-tumor therapy.
血管内皮细胞生长因子及其受体在肿瘤新生血管形成中起重要作用，成为肿瘤治疗的新靶点。
Vascular endothelial growth factor (VEGF) and its receptor play a critical role in tumor associated angiogenesis and has become the new targets of anti tumor therapy.
但是不管时间有多长，任何药物的结构改变都会改变他们对靶点的作用能力。
Any alteration of a drug's structure, however, will change its ability to interact with its target, regardless of the length of time involved.
近几年来，基质金属蛋白酶因在肿瘤的生长、转移和血管生成等多个环节中发挥着重要作用而成为肿瘤治疗研究中引人注目的新靶点。
Matrix metalloproteinases (MMPs) has been viewed as a promising target in tumor therapy in recent years due to their key role in tumor growth, angiogenesis, invasion and metastasis.
首次发现作用于细菌外壁令人琢磨不透的药物靶点详尽图像给科学家提供足够的新信息以帮助设计新型抗生素。
The first detailed images of an elusive drug target on the outer wall of bacteria may provide scientists with enough new information to aid design of novel antibiotics.
基质金属蛋白酶(MMP)因其在肿瘤的生长、转移和血管生成等多个环节中发挥着重要作用而成为肿瘤治疗研究中引人注目的靶点。
Matrix metalloproteinases (MMPs) has been viewed as a promising target in tumor therapy due to their key role in tumor growth, angiogenesis, invasion and metastasis.
基质金属蛋白酶(MMP)因其在肿瘤的生长、转移和血管生成等多个环节中发挥着重要作用而成为肿瘤治疗研究中引人注目的靶点。
Matrix metalloproteinases (MMPs) has been viewed as a promising target in tumor therapy due to their key role in tumor growth, angiogenesis, invasion and metastasis.
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