主要介绍了含亲电基团的荧光探针检测生物体系中毓基化合物及还原型谷胱甘肽硫转移酶活性的研究进展，并提出本论文的研究设想。
This dissertation consists of five chapters summarized as follows:In chapter 1, the research progress on fluorescent probes containing electrophilic moiety for thiols and GST were summarized.
并且对亲核试剂的体积效应、溶剂效应对亲核性影响，底物上吸电子基团的数目、吸电子能力对亲电性的影响，以及亲核取代反应的发生部位受哪些因素影响进行探讨。
At the same time, discuss about the impact factor to nucleophilicity such as the number of attract electron group, ability of attract electron and the nucleophilic substitution reaction part.
卤原子作为炔烃三键活化基团和定位基，炔烃三键发生亲电加成反应；
This type of reaction has signicant advantages, the alkyne proceeds the coupling reaction with the halogen atom as the leaving group.
卤原子作为炔烃三键活化基团和定位基，炔烃三键发生亲电加成反应；
This type of reaction has signicant advantages, the alkyne proceeds the coupling reaction with the halogen atom as the leaving group.
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