综述了组蛋白去乙酰酶抑制剂的药理作用及其临床应用前景。
The pharmacological actions of histone deacetylase inhibitors and their potential clinical use…
综述了组蛋白去乙酰酶抑制剂的药理作用及其临床应用前景。
The pharmacological actions of histone deacetylase inhibitors and their potential clinic…
本文就甲壳素脱乙酰酶在壳聚糖制备中的应用及研究进展作一综述。
In this paper, advances in the application and research of chitin deacetylase in preparation of chitosan are summarized.
组蛋白去乙酰酶抑制剂降低抗原提呈小鼠骨髓来源的树突状细胞的活性。
Histone deacetylase inhibitors decrease the antigen presenting activity of murine bone marrow derived dendritic cells.
组蛋白乙酰转移酶和组蛋白去乙酰酶活性共同决定了组蛋白的乙酰化水平。
The level of his-tone acetylation is determined by the activities of histone acetyltransferases and histone deacetylases.
从国内大肠杆菌菌株1.505提取磷酸转乙酰酶（PTA），经数步纯化荻得了高比活力酶制品。
A process of purification of PTA from E. Coli 1,505 with high specific activity has been reported in this paper.
组蛋白去乙酰酶抑制剂可提高组蛋白的乙酰化水平，并对一些非组蛋白成分产生影响，从而调节某些特定基因的表达。
Histone deacetylase inhibitors increase the acetylation level of histone as well as some non-histone proteins, and specifically modulate some gene expression.
作者另外还附上了一些实验结果来支撑他们的研究成果，例如，药物的羟肟羟胺酸，它们能够抑制脱乙酰酶，起到类似尼古丁的作用。
The authors backed up their results with additional experiments showing, for example, that the drug suberoylanilide hydroxamine acid, which inhibits deacetylases, simulates the effect of nicotine.
这项刊登在《预防癌症研究》刊物中的研究结果也指出，女性摄取萝卜硫素后，不但癌细胞增长减缓，就连组蛋白脱乙酰酶活性也降低。
In the new study published in the journal cancer Prevention Research, the intake of sulforaphane did reduce HDAC activity, as well as cancer cell growth.
乙酰-D-葡萄糖胺2-差向异构酶基因的克隆及表达。
Cloning and expression of N-acetyl-D-glucosamine2-epimerase.
一个是TSA，它可以抑制去除乙酰基的酶。
One, called TSA, inhibits the enzyme that removes acetyl groups.
为了逆转记忆遗失，医生在复合物中添加了组蛋白脱乙酰基酶抑制物。
To reverse the memory loss, doctors inject a compound called a histone deacetylase inhibitor.
这两种酶是组蛋白乙酰转移酶(它能给蛋白质添加乙酰基)和甲基化dna结合蛋白- 2(它能把DNA上的甲基去除)。
The enzymes in question are histone acetyltransferase (which adds acetyl groups to proteins) and methylated DNA-binding protein-2 (which removes methyl groups from DNA).
研究人员将变异酶、少量的神经毒气和乙酰胆碱酯酶一同放置于试管中。
The mutated enzymes were then put in a test tube with a small amount of nerve agent and the acetylcholinesterase.
这能有助于一种叫做肉碱乙酰转移酶的线粒体酶的活动。
These help a mitochondrial enzyme called carnitine acetyl transferase to do its job.
而在神经与肌肉之间充当“信使”的是一种叫做乙酰胆碱酯的酶，神经毒气正是通过抑制这种酶的工作来发挥作用的。
The gas inhibits acetylcholinesterase, an enzyme responsible for the breakdown of a chemical messenger responsible for muscle control, which is how it causes much of its ill effects.
如果乙酰胆碱酯酶能够正常工作，那么就意味着新的变异酶成功地降解了神经毒气。
If the acetylcholinesterase continued to function normally, Tawfik concluded that the mutated enzyme had successfully degraded the nerve agent.
DNA周围的学习和记忆基因束靠近乙酰基群，注入一种能促进乙酰基群变成任何一种组蛋白分子的酶。
The cluster of learning and memory genes on the surrounding DNA ends up close to the acetyl group.
这两种分子有助于被称作肉碱乙酰转移酶的线粒体酶发挥作用。
These help a mitochondrial enzyme called carnitine acetyltransferase to do its job.
这些药物通过抑制在神经肌肉接合部位水解乙酰胆碱的乙酰胆碱酯酶的活性而发挥效应。
These drugs exert their effect by inhibiting the activity of acetylcholinesterase, the enzyme that hydrolyzes acetylcholine in the neuromuscular junction.
在这样的情况下乙酰胆碱酯酶将以简单扩散的方式进入唾液，因此它的活性必将和唾液流量速率相关。
However, under these circumstances cholinesterase would enter the saliva by simple diffusion and therefore activity should be correlated with salivary flow rate.
此外，组蛋白乙酰转移酶的活性对HIV的增殖是必要的，至少一个科学小组建议组蛋白乙酰转移酶或相似的酶做为靶点也许是抑制病毒一个新方式。
In addition, hat activity is necessary for the multiplication of HIV, leading at least one scientific group to suggest that targeting HATs or similar enzymes might be an new way to thwart the virus.
目的：探讨组蛋白去乙酰化酶抑制剂MS- 275诱导人多发性骨髓瘤细胞株u266凋亡的分子机制。
OBJECTIVE: to investigate the molecular mechanisms of histone deacetylase inhibitor MS-275 on apoptosis of human myeloma U266 cell line.
糖酵解产生的丙酮酸在正常条件下被丙酮酸脱氢酶(PDH)转化成乙酰辅酶a (1 - 3)。
Pyruvate generated from glycolysis is converted to acetyl-CoA by pyruvate dehydrogenase (PDH) under normoxia (1-3).
建立以氯霉素乙酰化酶(CAT)为报告基因的雄激素受体(AR)报告基因试验。
To develop an androgen receptor (AR) reporter gene assay in which the reporter gene is chloramphenicol acetyltransferase (CAT).
本文研究了V类毒剂与乙酰胆碱酯酶的作用方式。
The mode of action of V-type organophosphate poisons on acetylcholinesterase has been studied.
本文研究了V类毒剂与乙酰胆碱酯酶的作用方式。
The mode of action of V-type organophosphate poisons on acetylcholinesterase has been studied.
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