认识到开发新颖治疗剂的要求，本发明提供新颖组蛋白去乙酰化酶抑制剂。
In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors.
本研究是对推测的小麦组蛋白乙酰转移酶及脱乙酰化酶基因功能研究的首次报道。
This is a first report about function study of histone acetyltransferase and deacetylase in wheat.
靶向DNA甲基化和组蛋白去乙酰化酶的几个表观药物已经在临床试验中被测试。
Several epigenetic drugs targeting DNA methylation and histone deacetylation enzymes have been tested in clinical trials.
建立以氯霉素乙酰化酶(CAT)为报告基因的雄激素受体(AR)报告基因试验。
To develop an androgen receptor (AR) reporter gene assay in which the reporter gene is chloramphenicol acetyltransferase (CAT).
目的研究组蛋白去乙酰化酶抑制剂MS275对人多发性骨髓瘤细胞U266增殖的影响。
ObjectiveTo investigate the antitumor effect of MS275, a histone deacetylase inhibitor, on growth of the human myeloma cell line U266.
抗肿瘤药罗米地辛是一种有效的组蛋白去乙酰化酶抑制剂，临床 上用于治疗皮肤T细胞淋巴瘤。
Romidepsin is a potent histone deacetylase inhibitor, and is used in the treatment of cutaneous T-cell lymphoma (CTCL).
组蛋白乙酰化和去乙酰化由一对功能相互拮抗的蛋白酶——组蛋白乙酰基转移酶和组蛋白去乙酰化酶负责。
The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other, which are histone transacetylase and histone deacetylase.
目的：探讨组蛋白去乙酰化酶抑制剂MS- 275诱导人多发性骨髓瘤细胞株u266凋亡的分子机制。
OBJECTIVE: to investigate the molecular mechanisms of histone deacetylase inhibitor MS-275 on apoptosis of human myeloma U266 cell line.
本文主要就组蛋白乙酰转移酶调节基因转录以及组蛋白去乙酰化酶抑制剂促进记忆形成的作用机理进行综述。
In this paper, we reviewed the mechanisms on histone acetyltransferases regulating gene transcription and histone deacetylase inhibitors promoting memory formation.
他们发现，大脑中有一个“开关”控制瘦素的作用，它就是一种名为组蛋白去乙酰化酶5（HDAC5）的酶。
They have discovered an enzyme - histone deacetylase 5 (HDAC5) - has a significant influence on the effect of the hormone.
我们期望，本次会议将评估去乙酰化酶生物学相关性的各种人类的条件，并提供一个独特的环境讨论特异性治疗策略。
We envision that this meeting will evaluate the relevance of sirtuin biology in various human conditions, and provide a unique environment for discussing specific therapeutic strategies.
本文综述了丁酸和植物提取物等饲料添加剂作为组蛋白去乙酰化酶(HDAC)抑制剂在模型动物及畜禽上的研究进展。
This review focused on the advances of the effect of feed additives, such as butyrate and plant extracts, on model animal and livestock as inhibitors of histone deacetylases (HDAC).
研究人员经过实验发现，通过去除哺乳动物细胞中的PSF或sin3 -组蛋白去乙酰化酶复合物，他们能够缩短生物钟周期的长度。
The researchers found that they could shorten the length of the circadian cycle by removing PSF or SIN3-histone deacetylase complex from mammalian cells.
Rattan博士认为老化是损伤的不断积累，而且老化并未从基因上得到严格的控制。他说，去乙酰化酶也许只是更纷繁复杂的情形中很小的一部分。
In his view, ageing is about the accumulation of damage, and is not under tight genetic control. Sirtuins will, he says, probably be but a small part of a more complicated picture.
组蛋白去乙酰酶抑制剂可提高组蛋白的乙酰化水平，并对一些非组蛋白成分产生影响，从而调节某些特定基因的表达。
Histone deacetylase inhibitors increase the acetylation level of histone as well as some non-histone proteins, and specifically modulate some gene expression.
综述了青霉素乙酰化固定化酶和头孢氨苄酶法缩合工艺的研究进展；
The advances in immobilized acetylase of penicillin and process of enzymatic condensation in cephalexin synthesis were reviewed.
组蛋白脱乙酰基酶与组蛋白脱乙酰基酶抑制剂通过对组蛋白乙酰化水平的调控，影响特定基因的表达，改变细胞周期的进程。
HDAC and histone deacetylase inhibitors (HDI) can affect expression of some specific genes and induce cell differentiation growth arrest and apoptosis through regulating histone acetylation level.
组蛋白乙酰转移酶和组蛋白去乙酰酶活性共同决定了组蛋白的乙酰化水平。
The level of his-tone acetylation is determined by the activities of histone acetyltransferases and histone deacetylases.
SIRT1蛋白，一种涉及到细胞衰老和DNA损伤反应的去乙酰基酶能够与p53结合，促使后者的去乙酰化（19）。
Deacetylation of p53 occurs through interaction with the SIRT1 protein, a deacetylase that may be involved in cellular aging and the DNA damage response (19).
背景：胆碱乙酰化转移酶是乙酰胆碱合成的关键酶，是胆碱能神经系统功能活动的重要标志。
BACKGROUND: the choline acetyltransferase (ChAT) is the key synthetic enzyme for acetylcholine, and is the important symbol of the functional activity of the cholinergic system.
组蛋白乙酰化与基因转录等生物效应有密切的关系，组蛋白乙酰化主要是由组蛋白乙酸转移酶催化的。
Histone acetylation has a close relation with some biological effects such as gene transcription, and is catalyzed by histone acetyltransferases.
目的探讨N 乙酰化转移酶1（NAT1）基因多态性与老年人胃肠腺癌易感性的关系。
Objective To analyze the association of N-acetyltransferase 1 (NAT1) genetic polymorphism with the susceptibility of elderly gastric adenocarcinoma (GAC) and colorectal adenocarcinoma (CRAC).
本文对大豆7S球蛋白的乙酰化、磷酸化及蛋白酶改性进行了研究，以蛋白质的持水性、乳化能力和吸油性为指标，评价改性效果。
The results indicated that both the modifications of chemistry and enzyme methods could take some meliorations to the function of Soybean 7S globulin.
本文对大豆7S球蛋白的乙酰化、磷酸化及蛋白酶改性进行了研究，以蛋白质的持水性、乳化能力和吸油性为指标，评价改性效果。
The results indicated that both the modifications of chemistry and enzyme methods could take some meliorations to the function of Soybean 7S globulin.
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