研究者发现，敲除FucM基因——这个基因影响了雌激素的水平，进而使大脑受到影响——使得雌性老鼠在长大过程中的行为仿佛就像雄性一样。
Researchers found that disabling the FucM gene - which influences the levels of oestrogen to which the brain is exposed - caused the mice to behave as if they were male as they grew up.
他们发现这种敲除基因的小鼠骨髓中的淋巴细胞较正常鼠少50%，产生特异免疫细胞的胸腺较正常鼠少80%。
They found that the knockout mice had 50 percent fewer lymphocytes in their bone marrow and 80 percent fewer in their thymus, a collection of glands that helps produce specialized immune cells.
在AEP基因敲除的小鼠实验中，该药物及人为中风所导致的DNA损伤与脑细胞死亡均比非基因敲除小鼠程度减轻。
In mice genetically engineered to lack AEP, both the drug and an artificial stroke resulted in reduced DNA damage and less brain cell death than in regular mice.
并且对基因敲除进行时空的调控，并成为脊椎动物成体中研究基因功能的重要手段。
Conditional gene knock-out has become an important means to research gene function in vertebrates.
并且对基因敲除进行时空的调控，并成为脊椎动物成体中研究基因功能的重要手段。
Moreover, it regulates gene knock-out spatially and temporally. Conditional gene knock-out has become an important means to research gene function in vertebrates.
这是因为在苍蝇中相对比较容易敲除一个基因的功能，然后尝试克隆这些基因敲除了的细胞，并检测这个被敲除的基因是否重要。
That is because it is relatively easy in flies to knock out the function of a single gene and then attempt cloning with these cells, which will test whether that gene is important.
拟南芥中，对敲除突变体的基因表达研究和分析有助于了解病害抗性路径的全貌。
In Arabidopsis, gene expression studies and analysis of knock-out (KO) mutants have been instrumental in building an integrated view of disease resistance pathways.
运用敲除、条件基因敲除或者过度表达的方法来改变发育过程中的基因表达，探讨在系统中出现的这些变化。
By changing gene expression patterns during development through knockouts, conditional knockouts, or overexpression, the changes in the system can be explored.
PML野生型和基因敲除细胞对抗癌药物LDM的反应提示正常细胞和癌细胞对抗肿瘤药物反应过程中PML蛋白不是唯一的途径。
The reaction of anticancer drug LDM with PML-wild-type and-knockout cells may elucidate that its not the unique pathway in the mechanism of LDM's action on normal and cancer cells.
Saltiel说：“在这项研究中，基因敲除的小鼠并没有比对照组小鼠进行更多的运动。”
"The knockout mice are not exercising any more than the control mice used in the study. They're just burning more energy," Saltiel said.
Saltiel说：“在这项研究中，基因敲除的小鼠并没有比对照组小鼠进行更多的运动。”
"The knockout mice are not exercising any more than the control mice used in the study. They're just burning more energy," Saltiel said.
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