1975年出生。2008年从湖南大学化学生物传感与计量学国家重点实验室毕业,获分析化学博士学位。从事硕博连读研究期间,于2006年破格加盟湖南大学化学化工学院。在影响因子高于5的期刊上发表学术论文10多篇；博士论文被推荐参与2011年全国优秀博士论文评选。主持国家自然科学基金一项；主研国家自然科学基金两项；曾获教育部自然科学一等奖、湖南省第十一届青年化学化工奖等奖项。2010年开始从事麦克马斯特大学博士后研究,是获得Michael G. DeGroote基金的第一位中国学者，2011年头条新闻该校生物学院对此做了专题报道 。目前研究领域主要涉及核酸与适体信号探针﹑核酸分子砌合器件﹑纳米生物技术与灵敏信号核酸操纵技术等方面（材料截止2011年5月）。

Selected Publications:

1. Li-Ping Qiu, Zai-Sheng Wu*, Guo-Li Shen, and Ru-Qin Yu*, Highly Sensitive and Selective Bifunctional Oligonucleotide Probe for Homogeneous Parallel Fluorescence Detection of Protein and Nucleotide Sequence, Analytical Chemistry, 2011, 83, 3050–3057

2. Zai-Sheng Wu,* Hui Zhou, Songbai Zhang, Guoli Shen,* and Ruqin Yu. Electrochemical Aptameric Recognition System for a Sensitive Protein Assay Based on Specific Target Binding-Induced Rolling Circle Amplification. Analytical Chemistry, 2010, 82 (6), 2282–2289

3. Zai-Sheng Wu, Songbai Zhang, Hui Zhou, Guo-Li Shen,* and Ruqin Yu.* Universal Aptameric System for Highly Sensitive Detection of Protein Based on Structure-Switching-Triggered Rolling Circle Amplification. Analytical Chemistry, 2010, 82 (6), 2221–2227.

4. Zai-Sheng Wu, * Haixia Lu, Xueping Liu, Rong Hu, Hui Zhou, Guoli Shen, * and Ru-Qin Yu. Inhibitory Effect of Target Binding on Hairpin Aptamer Sticky-End Pairing-Induced Gold Nanoparticle Assembly for Light-up Colorimetric Protein Assay. Analytical Chemistry, 2010, 82, 3890–3898

5. Jing-Lin He, Zai-Sheng Wu,* Hui Zhou, Hong-Qi Wang, Jian-Hui Jiang, Guo-Li Shen, and Ru-Qin Yu*. Fluorescence Aptameric Sensor for Strand Displacement Amplification Detection of Cocaine. Analytical Chemistry, 2010, 82, 1358–1364

6. Songbai Zhang, Rong Hu, Peng Hu, Zai-Sheng Wu,* Guo-Li Shen,* and Ru-Qin Yu, Background current-free electrochemical aptameric sensing platform for ultrasensitive signal-on detection of small molecule. Nucleic Acids Research, 2010, 38 (20), e185

7. Zaisheng Wu,* Hui Zhou, Songbai Zhang, Xiaobing Zhang, Guoli Shen* and Ruqin Yu, Pendulum-type optical DNA nanodevice. Chemical Communications, 2010, 46, 2232–2234.

8. Zai-Sheng Wu, Fan Zheng, Guo-Li Shen,* Ru-Qin Yu, A hairpin aptamer-based electrochemical biosensing platform for the sensitive detection of proteins. Biomaterials, 2009, 30, 2950-2955

9. Zai-Sheng Wu, Meng-Meng Guo, Song-Bai Zhang, Chen-Rui Chen, Jian-Hui Jiang, Guo-Li Shen* and Ru-Qin Yu,* Reusable electrochemical sensing platform for highly sensitive detection of small molecules based on structure-switching signaling aptamers, Analytical Chemistry, 2007, 79(7), 2933-2939

10. Zai-Sheng Wu, Jian-Hui Jiang, Guo-Li Shen,* and Ru-Qin Yu, Highly sensitive DNA detection and point mutation identification: an electrochemical approach based on the combined use of ligase and reverse molecular beacon, Human Mutation, 2007, 28(6): 630-637