生物体蛋白质的 “ 转录 / 翻译 ” 与 “ 降解 ” 是同样重要的命题。人们在 “ 转录和翻译 ” 的研究中取得了众所周知的突破。可以预见, 对蛋白质是如何被特一性降解的研究, 必将对生命科学的发展产生重要影响。
该实验室主要采用植物分子遗传、生物化学、功能基因组和蛋白组学等方法 , 研究蛋白降解途径和植物激素调控植物生长发育及抗性的机理。
Selected Publications:
■Xie,D, Feys,B.F., James,S., Nieto-Rostro,M., and Turner,J.G. (1998) COI1: an Arabidopsis gene required for jasmonate-regulated defense and fertility. Science 280:1091-1094.
■ Xu,L., Liu,F., Lechner,E., Genschik,P., Crosby,W.L., Ma,H., Peng,W., Huang,D., and Xie,D. (2002) The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis. Plant Cell 14:1919-1935.
■ Liu,F., Ni,W., Griffith,M.E., Huang,Z., Chang,C., Peng,W., Ma,H., and Xie,D. (2004) The ASK1 and ASK2 Genes Are Essential for Arabidopsis Early Development. Plant Cell 16:5-20.
■ Xiao, S., Dai, L., Liu, L., Wang,Z., Peng, W., and D Xie. (2004) COS1: an Arabidopsis coi1 suppressor essential for regulation of jasmonate-mediated plant defense and senescence. Plant Cell 16: 1132-42.
■ Ren C, J Pan, W Peng, P Genschik, L Hobbie, H Hellmann, M Estelle, B Gao, J Peng, C Sun, Xie D (2005) Point mutations in Arabidopsis Cullin1 reveal its essential role in jasmonate response. Plant J 42, 514524.
