生殖与生育的调节机制
主要研究兴趣:
1) 配子形成过程中减数分裂同源染色体不分离(nondisjunction)的机制及调控 (如年龄、环境因素)。
2) 女性生殖/生育相关的重要疾病如多囊卵巢综合征 (PCOS)、自发流产、不孕症等动物模型的建立、病因学及发病机制 (涉及到遗传因素、神经内分泌、代谢、免疫、蛋白组学等诸多领域)、治疗策略 (涉及到基因治疗、传统医学如中药治疗等领域) 的研究。
3) 男性不育发生的分子机制。
4) 精-卵融合前的“对话”机制。
主要在研课题:
中国科学院“百人计划”启动经费课题
主要代表论文(近5年):
1. Sun F(孙斐), Oliver-Bonet M, Liehr T, Starke H, Ko E, Rademaker A, Navarro J, Benet J, Martin RH. Human male recombination maps for individual chromosomes. Am J Hum Genet 74: 521-531,2004. The paper was highlighted in Am J Hum Genet, 2004, 74: і- іі. IF= 12.649
2. Sun F(孙斐), Oliver-Bonet M, Liehr T, Starke H, Turek P, Ko E, Rademaker A, Martin RH. Variation in MLH1 distribution in recombination maps for individual chromosomes from human males. Hum Mol Genet 15(15):2376-2391,2006. 本文被选作杂志封面, IF= 7.764
3. Sun F(孙斐), Oliver-Bonet M, Liehr T, Starke H, Trpkov K, Ko E, Rademaker A, Martin RH. Discontinuous and unpaired regions in meiotic chromosome have a cis effect on meiotic recombination patterns in normal human males. Hum Mol Genet 14 (20): 3013-3018,2005. IF=7.764
4. Sun F(孙斐), Giojalas LC, Rovasio RA, Tur-Kaspa I, Sanchez R, Eisenbach M. Lack of species- specificity in mammalian sperm chemotaxis. Dev Biol 255 (2): 423-427,2003. IF=5.234
5. Sun F(孙斐), Trpkov K, Rademaker A, Ko E, Martin RH. Variation in meiotic recombination frequencies among human males. Hum Genet 116 (3): 172-178,2005. IF=4.331
6. Sun F(孙斐), Oliver-Bonet M, Liehr T, Starke H, Turek P, Ko E, Rademaker A, Martin RH. Analysis of non-crossover bivalents in pachytene cells from 10 normal men. Hum Reprod 21(9):2335-2339, 2006. 本文被选作杂志封面,IF= 3.669
7. Sun F(孙斐), Kozak G, Scott S, Trpkov K, Ko E, Mikhaail-Philips M, Bestor TH, Moens P, Martin RH. Meiotic defects in a man with non-obstructive azoospermia: Case report. Hum Reprod 19 (8): 1770-1773,2004. 本文被选作杂志封面, IF=3.669
8. Sun F(孙斐), Bahat A, Gakamsky A, Girsh E, Katz N, Giojalas LC, Tur-Kaspa I, Eisenbach M. Human sperm chemotaxis: both the oocyte and its surrounding cumulus cells secrete sperm chemoattractants. Hum Reprod 20 (3): 761-767,2005. IF=3.669
9. Sun F(孙斐), Oliver-Bonet M, Turek PJ, Ko E, Martin RH. Meiotic study on (Y; 1) translocation in a male with azoospermia. Mol Hum Reprod 11 (5): 361-364,2005. 本文被选作杂志封面, IF=3.191
10. Sun F(孙斐), Yu J. The effect of a special herbal tea on obesity and anovulation in androgen-sterilized rats. Exp Biol Med 223 (3): 295-301,2000. IF=2.369
11. Sun F(孙斐), Greene C, Turek PJ, Ko E, Rademaker A, Martin RH. Immunofluorescent synaptonemal complex analysis in azoospermic men. Cytogenet Genome Res 111(3-4): 366-370,2005. IF=2.076