目的:对阿司匹林鼻粘膜给药淀粉微球的制备工艺进行考察,并评价其体外质量。
OBJECTIVE To study the preparation of aspirin-carrying starch microspheres as nasal administration and evaluate its quality in-vitro.
方法:以TDI为致敏原,对豚鼠行鼻内给药法建立鼻超敏反应模型,以息斯敏为对照,对鼻粘膜组胺含量进行观察。
Method: TDI selected for allergen, which was used in nose to establish guinea pig allergic rhinitis, Xisimin was used for contrast drug to observe the quantity of nasal mucosa histamine.
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