当PIDD水平在肺癌细胞人为增加时，它们对顺铂耐药性增强。

When PIDD levels are artificially increased in human lung cancer cells, they become more resistant to cisplatin.

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现在，MIT癌症生物学家已经展现了耐药性是如何增加的，这项发现可能帮助研究员设计可以克服顺铂耐药性的新药。

Now, MIT cancer biologists have shown how that resistance arises, a finding that could help researchers design new drugs that overcome cisplatin resistance.

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顺铂通常第一次给药时有效，它有一个主要的缺陷：肿瘤获得耐药性，而且重新开始生长。

While cisplatin is often effective when first given, it has a major drawback: Tumors can become resistant to the drug and start growing again.

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