目的：探讨非靶位基因突变及外膜通透性改变对大肠杆菌喹诺酮类耐药和多重耐药的影响。

Objective To investigate the impact of non target gene mutations and reduced permeability of the outer membrane on quinolone resistance and multiple antibiotic resistance (mar) in Escherichia coli.

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目的探讨大肠埃希菌靶位基因突变对喹诺酮类药物耐药的影响。

Objective To investigate the effects of target gene mutations on the quinolones resistance in Escherichia coli.

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目的：研究不同药物浓度、不同化学结构的氟喹诺酮类药物对突变选择窗(MSW)内筛选的大肠埃希菌耐药突变体的靶位耐药基因的影响。

OBJECTIVE To investigate the effect of drug concentration, drug structure of fluoroquinolones on the resistant gene of Escherichia coli mutants selected in the mutant selection window (MSW).

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