特别地，在非蛋白质编码部分选择如何工作，选择丢弃什么样的变异：少数常见基因影响小或者许多罕见基因影响大？
In particular, how does it work on the non-protein-coding parts, and what kinds of variation does it leave behind: a few common genes with small effects or many rare genes with large effects?
这一细节让他们作出结论：可能是遗传获得的非编码DNA序列、而不是基因变异才使得最大部分的转录因子结合位置发生变化。
This detail led them to conclude that inherited non-coding DNA sequences – not mutations in genes – may drive the lion's share of differences in where transcription factors attach.
特别地，在非蛋白质编码部分选择如何工作，选择丢弃什么样的变异：少数常见基因影响小或者许多罕见基因影响大？
In particular how does it work on the non-protein-coding parts and what kinds of variation does it leave behind: a few common genes with small effects or many rare genes with large effects?
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