烟草能显著地提高伤寒沙门氏菌突变率和CHO细胞集落形成率；

Tobacco increased significantly the mutation rate of Salmonella typhia and the formation rate of CHO colony.

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结果：MAPK反义寡核苷酸可明显抑制细胞活力、蛋白质含量、集落形成和DNA合成，其抑制率分别为52。6%、50。5%、54。9%和47。5%，与对照组比较差异有显著性（P<0。01）。

Results The cell viability, protein content, colony formation and DNA synthesis were significantly inhibited by MAPK ASO, the inhibitory rate was 52.6% , 50.5% , 54.9% and 47.5% respectively(P< 0.01).

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结果显示永生化胚胎肝细胞克隆形成率为31.2%，染色体核型分析表明细胞核型无明显异常，软琼脂集落形成试验表明细胞在软琼脂中不能生长。

It is showed that the cell clone-forming rat was 31. 2%. The immortalized human fetal hepatocytes had a normal karyotype and were not able to grow in soft AGAR culture.

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