介绍多种疾病亚型、各中心分配例数不等的临床试验随机化方案的设计。
A design for randomized protocol of multi-center clinical trial dealing with multi-subtype disease and unequally distributed cases in centers was introduced in this article.
改进方案均修改了每个签名者的随机化处理过程，并转移了部分计算操作。
The random operation of each signer was changed, and part of computation operation was transferred in both of the improved schemes.
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