阿托品阻断M胆碱受体，使瞳孔括约肌和睫状肌松弛，导致去甲肾上腺素能神经支配的瞳孔扩大肌的功能占优势，从而使瞳孔散大。瞳孔散大把虹膜推向虹膜角膜角，妨碍房水通过小梁网排入巩膜静脉窦，引起眼压升高。阿托品使睫状肌松弛，拉紧悬韧带使晶状体变扁平，减低其屈光度，引起调节麻痹，处于看远物清楚，看近物模糊的状态。
目的对阿托品眼膏的微生物限度检查进行方法验证。
Objective To verify the microbial limit test for atropine eye ointment.
结论对阿托品眼膏的微生物限度检查可按常规法进行。
Conclusion The microbial limit test of atropine eye ointment could be investigated by conventional method.
方法在阿托品眼膏中加入5种阳性对照菌，测定其回收率，验证常规法测定阿托品眼膏中菌数方法的可靠性。
Methods 5 bacterial liquids as positive controls were respectively added into atropine eye ointment and the relative recovery rates were determined.
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