筛选以2-溴代丁酸为起始原料,经氨解,酯化,酯胺解,拆分,环合五步反应制得左乙拉西坦。
Screening for 2 - bromo- butyric acid as the starting material, after ammonolysis, esterification, ester amine solution, split, five-step cyclization reaction Levetiracetam.
筛选以2 -溴代丁酸为起始原料,经氨解,酯化,酯胺解,拆分,环合五步反应制得左乙拉西坦。
Screening for 2 - bromo-butyric acid as the starting material, after ammonolysis, esterification, ester amine solution, split, five-step cyclization reaction Levetiracetam.
根据动力学曲线获得了乙撑碳酸酯与三种有机胺在不同反应条件下发生胺解反应的速率常数。
The aminolysis reaction rate constants of ethylene carbonate by ethanolamine, diethanolamine and butylamine were obtained according to the kinetic curves under different reaction conditions.
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