设计合适的核酶分子能够阻断癌基因的异常表达，逆转肿瘤细胞MDR，促进肿瘤细胞凋亡，有望成为肿瘤基因治疗的有效手段之一。

With appropriate designing, it could block oncogene's expression, reverse MDR, and promote tumor cell apoptosis. All these properties make the Ribozymes as potentially useful regent for gene therapy.

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目的：探讨端粒酶逆转录酶(TERT)的反义寡核苷酸(A SODN)对甲状腺癌(TC)细胞凋亡的影响。

AIM: to investigate the effect of antisense oligonucleotides (ASODN) encoding telomerase reverse transcriptase (TERT) mRNA on thyroid carcinoma (TC) cell apoptosis.

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蛋白酶体抑制剂可选择性地促进肿瘤细胞凋亡，逆转多药耐药。

Proteasome inhibitors can selectively promote the apoptosis of tumor cells and overcome MDR.

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