当原纤维遭到破坏或者缺失就像混凝土缺少钢筋一样，骨性关节炎就会发生。软骨的机械性变弱易于磨损和撕裂。
Osteoarthritis occurs when the fibrils are disrupted or lost - just like concrete without the steel, the cartilage becomes mechanically weak and susceptible to wear and tear.
而超微结构改变以软骨细胞破碎的比较多见，有的软骨细胞则增生，基质胶原原纤维明显减少。
Many broken cartilage cells could be observed and matrix collagenous fibril decreases obviously, but some cartilage cells proliferated.
结论纤维蛋白原胶可以用于粘合软骨修复材料，化学性医用胶对软骨修复材料和修复部位有损害作用。
Conclusion Fibrinogen glue can been used to conglutinate repairing cartilaginous materials. The chemical glue can lesion repairing materials and sites.
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